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OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) ELISA Kits

The product of OTUB1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Antibodies (120) and OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (20) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse OTUB1 OTUB1 107260 Q7TQI3
Anti-Human OTUB1 OTUB1 55611 Q96FW1
Anti-Rat OTUB1 OTUB1 293705 B2RYG6
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More ELISA Kits for OTU Domain, Ubiquitin Aldehyde Binding 1 Interaction Partners

Pig (Porcine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym (show PTMA ELISA Kits)

Human OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 (show FOXM1 ELISA Kits) in breast cancer and has a key role in genotoxic agent resistance.

  2. substrate for hydroxylation by FIH (show CASR ELISA Kits) on N22

  3. Data show that casein kinase 2 (CK2 (show CSNK2A1 ELISA Kits))-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1.

  4. OTUB1 promoted the metastasis of CRC (show CALR ELISA Kits) cell lines.

  5. After viral infection, HSCARG (show NMRAL1 ELISA Kits) interacted with tumor necrosis receptor-associated factor 3 (TRAF3 (show TRAF3 ELISA Kits)) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3 (show TRAF3 ELISA Kits).

  6. These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 (show UBE2D1 ELISA Kits) and the function to suppress it.

  7. OTUB1 enhances TGF-beta (show TGFB1 ELISA Kits) signaling by inhibiting the ubiquitylation and degradation of active SMAD2 (show SMAD2 ELISA Kits) and SMAD3 (show SMAD3 ELISA Kits).

  8. A second role of OTUB1-E2 interactions is to stimulate OTUB1 cleavage of Lys48 polyubiquitin. This stimulation is regulated by the ratio of charged to uncharged E2 and by the concentration of Lys48-linked polyubiquitin and free ubiquitin.

  9. These results suggest that OTUB1 regulates NF-kappaB (show NFKB1 ELISA Kits) and MAPK (show MAPK1 ELISA Kits) signalling pathways and TNF (show TNF ELISA Kits)-dependent cell death by modulating c-IAP1 (show BIRC2 ELISA Kits) stability.

  10. the crystal structure of human OTUB1 in complex with human UBC13 (show UBE2N ELISA Kits) and MMS2 (show UBE2V2 ELISA Kits)

OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Antigen Profile

Antigen Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with OTUB1

  • OTU domain, ubiquitin aldehyde binding 1 (OTUB1) antibody
  • OTU domain, ubiquitin aldehyde binding 1b (otub1b) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (otub1) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (Otub1) antibody
  • similar to HSPC263 (RGD1565010) antibody
  • AI850305 antibody
  • fa19h07 antibody
  • MGC131231 antibody
  • OTB1 antibody
  • OTU1 antibody
  • otub1 antibody
  • wu:fa19h07 antibody
  • zgc:92839 antibody

Protein level used designations for OTUB1

ubiquitin thioesterase OTUB1 , OTU domain, ubiquitin aldehyde binding 1 , otubain 1 , Ubiquitin thioesterase OTUB1 , ubiquitin thioesterase otub1 , OTU domain-containing ubiquitin aldehyde-binding protein 1 , deubiquitinating enzyme OTUB1 , otubain-1 , ubiquitin-specific-processing protease OTUB1 , OTU-domain Ubal-binding 1 , ubiquitin-specific protease otubain 1

GENE ID SPECIES
100302092 Sus scrofa
436773 Danio rerio
476039 Canis lupus familiaris
717989 Macaca mulatta
734823 Xenopus laevis
742797 Pan troglodytes
100286700 Salmo salar
100529028 Ictalurus punctatus
107260 Mus musculus
55611 Homo sapiens
540984 Bos taurus
293705 Rattus norvegicus
611228 Canis lupus familiaris
314660 Rattus norvegicus
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