You are viewing an incomplete version of our website. Please click to reload the website as full version.

OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (OTUB1)

The product of OTUB1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Antibodies (120) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OTUB1 107260 Q7TQI3
OTUB1 55611 Q96FW1
OTUB1 293705 B2RYG6
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins at antibodies-online.com

Showing 10 out of 20 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 16 Days
$140.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$633.60
Details
HOST_Escherichia coli (E. coli) Human GST tag 1 mg Log in to see 7 to 9 Days
$1,842.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Rat His tag   100 μg Log in to see 11 to 13 Days
$704.00
Details
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
$739.20
Details

OTUB1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,
Rat (Rattus) ,

Top referenced OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins

  1. Human OTUB1 Protein expressed in Escherichia coli (E. coli) - ABIN2005357 : Choudhary, Kumar, Gnad, Nielsen, Rehman, Walther, Olsen, Mann: Lysine acetylation targets protein complexes and co-regulates major cellular functions. in Science (New York, N.Y.) 2009 (PubMed)
    Show all 5 references for ABIN2005357

  2. Human OTUB1 Protein expressed in Escherichia coli (E. coli) - ABIN667122 : Balakirev, Tcherniuk, Jaquinod, Chroboczek: Otubains: a new family of cysteine proteases in the ubiquitin pathway. in EMBO reports 2003 (PubMed)
    Show all 2 references for ABIN667122

More Proteins for OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Interaction Partners

Pig (Porcine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym (show PTMA Proteins)

Human OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 (show FOXM1 Proteins) in breast cancer and has a key role in genotoxic agent resistance.

  2. substrate for hydroxylation by FIH (show CASR Proteins) on N22

  3. Data show that casein kinase 2 (CK2 (show CSNK2A1 Proteins))-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1.

  4. OTUB1 promoted the metastasis of CRC (show CALR Proteins) cell lines.

  5. After viral infection, HSCARG (show NMRAL1 Proteins) interacted with tumor necrosis receptor-associated factor 3 (TRAF3 (show TRAF3 Proteins)) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3 (show TRAF3 Proteins).

  6. These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 (show UBE2D1 Proteins) and the function to suppress it.

  7. OTUB1 enhances TGF-beta (show TGFB1 Proteins) signaling by inhibiting the ubiquitylation and degradation of active SMAD2 (show SMAD2 Proteins) and SMAD3 (show SMAD3 Proteins).

  8. A second role of OTUB1-E2 interactions is to stimulate OTUB1 cleavage of Lys48 polyubiquitin. This stimulation is regulated by the ratio of charged to uncharged E2 and by the concentration of Lys48-linked polyubiquitin and free ubiquitin.

  9. These results suggest that OTUB1 regulates NF-kappaB (show NFKB1 Proteins) and MAPK (show MAPK1 Proteins) signalling pathways and TNF (show TNF Proteins)-dependent cell death by modulating c-IAP1 (show BIRC2 Proteins) stability.

  10. the crystal structure of human OTUB1 in complex with human UBC13 (show UBE2N Proteins) and MMS2 (show UBE2V2 Proteins)

OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Protein Profile

Protein Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with OTUB1

  • OTU domain, ubiquitin aldehyde binding 1 (OTUB1)
  • OTU domain, ubiquitin aldehyde binding 1b (otub1b)
  • OTU domain, ubiquitin aldehyde binding 1 (otub1)
  • OTU domain, ubiquitin aldehyde binding 1 (Otub1)
  • similar to HSPC263 (RGD1565010)
  • AI850305 protein
  • fa19h07 protein
  • MGC131231 protein
  • OTB1 protein
  • OTU1 protein
  • otub1 protein
  • wu:fa19h07 protein
  • zgc:92839 protein

Protein level used designations for OTUB1

ubiquitin thioesterase OTUB1 , OTU domain, ubiquitin aldehyde binding 1 , otubain 1 , Ubiquitin thioesterase OTUB1 , ubiquitin thioesterase otub1 , OTU domain-containing ubiquitin aldehyde-binding protein 1 , deubiquitinating enzyme OTUB1 , otubain-1 , ubiquitin-specific-processing protease OTUB1 , OTU-domain Ubal-binding 1 , ubiquitin-specific protease otubain 1

GENE ID SPECIES
100302092 Sus scrofa
436773 Danio rerio
476039 Canis lupus familiaris
717989 Macaca mulatta
734823 Xenopus laevis
742797 Pan troglodytes
100286700 Salmo salar
100529028 Ictalurus punctatus
107260 Mus musculus
55611 Homo sapiens
540984 Bos taurus
293705 Rattus norvegicus
611228 Canis lupus familiaris
314660 Rattus norvegicus
Selected quality suppliers for OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (OTUB1)
Did you look for something else?