OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) ELISA Kits

The product of OTUB1 is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 1 Antibodies (129) and OTU Domain, Ubiquitin Aldehyde Binding 1 Proteins (21) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse OTUB1 OTUB1 107260 Q7TQI3
Anti-Human OTUB1 OTUB1 55611 Q96FW1
Anti-Rat OTUB1 OTUB1 293705 B2RYG6
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More ELISA Kits for OTU Domain, Ubiquitin Aldehyde Binding 1 Interaction Partners

Pig (Porcine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. OTUB1 localizes predominantly in the nucleus and is highly expressed in the brain, liver, spleen, lung, kidney, large intestine, small intestine, stomach, ovary, uterus and thym (show PTMA ELISA Kits)

Mouse (Murine) OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. GRAIL (show RNF128 ELISA Kits) expression is regulated by the IL2 (show IL2 ELISA Kits)/mTOR (show FRAP1 ELISA Kits)/Otubain-1 axis in CD4 (show CD4 ELISA Kits) T cells during Trypanosoma cruzi infection.

  2. Otub1 as a Tau deubiquitinase in vitro and in vivo, involved in formation of pathological Tau forms, including small soluble oligomeric forms

Human OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) interaction partners

  1. Data indicate that knockdown of otubain 1 protein (Otub1) reduced the levels of double minute 4 protein (MDMX (show MDM4 ELISA Kits)).

  2. OTUB1 may play an important role in colon cancer development and metastasis.

  3. An increase of OTUB1 expression is commonly observed in non-small-cell lung carcinomas harboring wild-type KRAS and is associated with increased levels of ERK1/2 (show MAPK1/3 ELISA Kits) phosphorylation, high Ki67 (show MKI67 ELISA Kits) score, and poorer patient survival.

  4. the data suggest that OTUB1 limits the ubiquitination and degradation of FOXM1 (show FOXM1 ELISA Kits) in breast cancer and has a key role in genotoxic agent resistance.

  5. substrate for hydroxylation by FIH (show CASR ELISA Kits) on N22

  6. Data show that casein kinase 2 (CK2 (show CSNK2A1 ELISA Kits))-mediated phosphorylation of deubiquitylating enzyme OTUB1 at Ser16 causes nuclear accumulation of OTUB1.

  7. OTUB1 promoted the metastasis of CRC (show CALR ELISA Kits) cell lines.

  8. After viral infection, HSCARG (show NMRAL1 ELISA Kits) interacted with tumor necrosis receptor-associated factor 3 (TRAF3 (show TRAF3 ELISA Kits)) and inhibited its ubiquitination by promoting the recruitment of OTUB1 to TRAF3 (show TRAF3 ELISA Kits).

  9. These data reveal novel insights into the Otub1 inhibition of E2 wherein monoubiquitination promotes the interaction of Otub1 with UbcH5 (show UBE2D1 ELISA Kits) and the function to suppress it.

  10. OTUB1 enhances TGF-beta (show TGFB1 ELISA Kits) signaling by inhibiting the ubiquitylation and degradation of active SMAD2 (show SMAD2 ELISA Kits) and SMAD3 (show SMAD3 ELISA Kits).

OTU Domain, Ubiquitin Aldehyde Binding 1 (OTUB1) Antigen Profile

Antigen Summary

The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with OTUB1

  • OTU domain, ubiquitin aldehyde binding 1 (OTUB1) antibody
  • OTU domain, ubiquitin aldehyde binding 1b (otub1b) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (otub1) antibody
  • OTU domain, ubiquitin aldehyde binding 1 (Otub1) antibody
  • similar to HSPC263 (RGD1565010) antibody
  • AI850305 antibody
  • fa19h07 antibody
  • MGC131231 antibody
  • OTB1 antibody
  • OTU1 antibody
  • otub1 antibody
  • wu:fa19h07 antibody
  • zgc:92839 antibody

Protein level used designations for OTUB1

ubiquitin thioesterase OTUB1 , OTU domain, ubiquitin aldehyde binding 1 , otubain 1 , Ubiquitin thioesterase OTUB1 , ubiquitin thioesterase otub1 , OTU domain-containing ubiquitin aldehyde-binding protein 1 , deubiquitinating enzyme OTUB1 , otubain-1 , ubiquitin-specific-processing protease OTUB1 , OTU-domain Ubal-binding 1 , ubiquitin-specific protease otubain 1

GENE ID SPECIES
100302092 Sus scrofa
436773 Danio rerio
476039 Canis lupus familiaris
717989 Macaca mulatta
734823 Xenopus laevis
742797 Pan troglodytes
100286700 Salmo salar
100529028 Ictalurus punctatus
107260 Mus musculus
55611 Homo sapiens
540984 Bos taurus
293705 Rattus norvegicus
611228 Canis lupus familiaris
314660 Rattus norvegicus
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