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OTUB2 encodes one of several deubiquitylating enzymes. Additionally we are shipping OTU Domain, Ubiquitin Aldehyde Binding 2 Antibodies (85) and OTU Domain, Ubiquitin Aldehyde Binding 2 Kits (1) and many more products for this protein.
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Human OTUB2 Protein expressed in Escherichia coli (E. coli) - ABIN2005521
Balakirev, Tcherniuk, Jaquinod, Chroboczek: Otubains: a new family of cysteine proteases in the ubiquitin pathway. in EMBO reports 2003
Show all 2 references for ABIN2005521
Human OTUB2 Protein expressed in Escherichia coli (E. coli) - ABIN667440
Edelmann, Iphöfer, Akutsu, Altun, di Gleria, Kramer, Fiebiger, Dhe-Paganon, Kessler: Structural basis and specificity of human otubain 1-mediated deubiquitination. in The Biochemical journal 2009
Show all 2 references for ABIN667440
OTUB2 fine-tunes the speed of double-strand break-induced ubiquitination so that the appropriate DNA repair pathway is chosen
OTUB2 is a novel promoter of via (show INS Proteins)bility and insulin secretion in human beta cells. OTUB2 acts through the inhibition of NF-kappaB signalling.
Findings suggest that OTUB1 (show OTUB1 Proteins) and OTUB2 negatively regulate virus-triggered type I IFN induction and cellular antiviral response by deubiquitinating TRAF3 (show TRAF3 Proteins) and -6.
Data report the first crystal structure of an OTU superfamily protein, otubain 2, at 2.1 A resolution and propose a model for otubain-ubiquitin binding.
siRNAs of OTUB2 impaired insulin (show INS Proteins) secretion both under basal conditions and in cytokine-treated MIN6 cells
This gene encodes one of several deubiquitylating enzymes. Ubiquitin modification of proteins is needed for their stability and function\; to reverse the process, deubiquityling enzymes remove ubiquitin. This protein contains an OTU domain and binds Ubal (ubiquitin aldehyde)\; an active cysteine protease site is present in the OTU domain.
OTU domain, ubiquitin aldehyde binding 2
, OTU domain-containing ubiquitin aldehyde-binding protein 2
, deubiquitinating enzyme OTUB2
, ubiquitin thioesterase OTUB2
, ubiquitin-specific protease otubain 2
, ubiquitin-specific-processing protease OTUB2