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anti-Oculocerebrorenal Syndrome of Lowe (OCRL) Antibodies

OCRL encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Additionally we are shipping OCRL Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OCRL 317576  
OCRL 4952 Q01968
OCRL 320634  
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Top anti-OCRL Antibodies at antibodies-online.com

Showing 10 out of 63 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated WB Western blot analysis of OCRL over-expressed 293 cell line, cotransfected with OCRL Validated Chimera RNAi used as specificity and loading control. Western Blot analysis of OCRL expression in transfected 293T cell line by OCRL monoclonal antibody (M02), clone 4A6. Lane 1: OCRL transfected lysate(103.2 KDa). Lane 2: Non-transfected lysate. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: OCRL Antibody [NBP1-80973] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: OCRL Antibody [NBP1-80973] - Staining of human kidney shows cytoplasmic positivity in cells of tubules. 0.1 mL Log in to see 8 to 11 Days
$439.69
Details
Human Mouse Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$566.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 14 Days
$175.80
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human breast cancer, using OCRL, antibody at 1:250 dilution. WB Image Sample (30 ug of whole cell lysate) A: 293T B: A431 5% SDS PAGE antibody diluted at 1:500 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB Western blot analysis of OCRL expression in HeLa (A), KNRK (B) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Mouse Un-conjugated ICC, IF, WB Immunocytochemistry/Immunofluorescence: OCRL Antibody (S166A-26) [NBP2-42193] - Tissue: Neuroblastoma cell line SK-N-BE. Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-INPP5F Monoclonal Antibody at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasmic Vesicle, Endosome, Endosome Membrane, Membrane, Golgi Apparatus, Nucleus. Magnification: 60X. Western Blot: OCRL Antibody (S166A-26) [NBP2-42193] - analysis of Monkey COS cells transfected with GFP-tagged OCRL showing detection of 100 kDa INPP5F protein using Mouse Anti-INPP5F Monoclonal Antibody, Clone S166A-26 . Lane 1: Molecular Weight Ladder. Lane 2: Monkey COS cells transfected with GFP-tagged OCRL. Load: 15 ug . Block: 2% BSA and 2% Skim Milk in 1X TBST. Primary Antibody: Mouse Anti-INPP5F Monoclonal Antibody at 1:200 for 16 hours at 4C. Secondary Antibody: Goat Anti-Mouse IgG: HRP at 1:1000 for 1 hour RT. Color Development: ECL solution for 6 min in RT. Predicted/Observed Size: 100 kDa. 0.1 mg Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: OCRL Antibody [NBP2-19621] - Immunohistochemical analysis of paraffin-embedded Breast ca, using antibody at 1:250 dilution. Western Blot: OCRL Antibody [NBP2-19621] - Sample (30 ug of whole cell lysate) A: 293T B: A431 5% SDS PAGE gel, diluted at 1:500. 0.1 mL Log in to see 6 to 9 Days
$447.56
Details
Human Rabbit Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 6 Days
$275.00
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 8 to 10 Days
$405.17
Details

OCRL Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Rat (Rattus)


Human ,
,
,
, , , , , , , , , , , , , , , ,
Mouse (Murine)


Top referenced anti-OCRL Antibodies

  1. Human Monoclonal OCRL Primary Antibody for WB - ABIN396192 : Swan, Tomasini, Pirruccello, Lunardi, De Camilli: Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 5 references for ABIN396192

  2. Human Polyclonal OCRL Primary Antibody for IHC, IHC (p) - ABIN4341304 : Bohdanowicz, Balkin, De Camilli, Grinstein: Recruitment of OCRL and Inpp5B to phagosomes by Rab5 and APPL1 depletes phosphoinositides and attenuates Akt signaling. in Molecular biology of the cell 2012 (PubMed)

More Antibodies against OCRL Interaction Partners

Zebrafish Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. OCRL1 is required for renal tubular endocytosis.

  2. Knockdown of OCRL1 in zebrafish caused developmental defects consistent with disruption of ciliary function.

  3. results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome

Human Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. Here we show that OCRL1 is part of the membrane-trafficking machinery operating at the trans-Golgi network (TGN (show TG Antibodies))/endosome interface.

  2. Authors propose that the precise spatial and temporal activation of Rab35 (show RAB35 Antibodies) acts as a major switch for OCRL recruitment on newborn endosomes, post-scission PtdIns(4,5)P2 hydrolysis, and subsequent endosomal trafficking.

  3. OCRL mRNA and protein were downregulated in osteoarthritis knee cartilage. OCRL inhibits Rac1 activation in OA.

  4. OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B (show INPP5B Antibodies)-independent phenotypic variability relatively to Lowe syndrome cells.

  5. Results indicate that inositol 5-phosphatase OCRL acts as an uncoating factor and that defects in clathrin-mediated endocytosis likely contribute to pathology in patients with OCRL mutations.

  6. The crystal structures of human OCRL in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer.

  7. Implications of OCRL and TRPV4 (show TRPV4 Antibodies) in primary cilia function may also shed light on mechanosensation in other organ systems.

  8. Dent disease is caused by mutations in at least two genes, i.e. CLCN5 (show CLCN5 Antibodies) and OCRL1, and its genetic background and phenotypes are common among European countries and the USA.

  9. Three Chinese children were diagnosed with Lowe syndrome through clinical and genetic analyses. And two novel mutations in the OCRL gene were identified

  10. a role of OCRL in cilia maintenance and suggest the involvement of ciliary dysfunction in the manifestation of Lowe syndrome.

Mouse (Murine) Oculocerebrorenal Syndrome of Lowe (OCRL) interaction partners

  1. OCRL mRNA and protein were downregulated in osteoarthritis knee cartilage. OCRL inhibits Rac1 activation in OA.

  2. Implications of OCRL and TRPV4 (show TRPV4 Antibodies) in primary cilia function may also shed light on mechanosensation in other organ systems.

  3. Bcl10 was required to locally deliver the vesicular OCRL phosphatase that regulates PI(4,5)P(2) and F-actin turnover, both crucial for the completion of phagosome closure.

  4. These results indicate a functional overlap of Ocrl and Inpp5b (show INPP5B Antibodies) in most cell lineages, especially in extraembryonic tissues.

  5. The results indicate that OCRL1 restricts intracellular growth of L. pneumophila and binds to Legionella-containing vacuoles in association with Legionella LpnE.

OCRL Antigen Profile

Protein Summary

This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease.

Gene names and symbols associated with OCRL

  • oculocerebrorenal syndrome of Lowe (Ocrl) antibody
  • phosphatidylinositol polyphosphate 5-phosphatase (NAEGRDRAFT_58601) antibody
  • oculocerebrorenal syndrome of Lowe (OCRL) antibody
  • oculocerebrorenal syndrome of Lowe (ocrl) antibody
  • 9530014D17Rik antibody
  • BB143339 antibody
  • INPP5F antibody
  • LOCR antibody
  • NPHL2 antibody
  • OCRL antibody
  • OCRL-1 antibody
  • OCRL1 antibody
  • wu:fi09g03 antibody
  • zgc:152864 antibody

Protein level used designations for OCRL

inositol polyphosphate 5-phosphatase OCRL-1 , phosphatidylinositol polyphosphate 5-phosphatase , phosphatidylinositol polyphosphate 5-phosphotase , oculocerebrorenal syndrome of Lowe , phosphatidylinositol polyphosphate 5-phosphatase-like , inositol polyphosphate 5-phosphatase OCRL-1-like , Lowe oculocerebrorenal syndrome protein

GENE ID SPECIES
317576 Rattus norvegicus
8851947 Naegleria gruberi strain NEG-M
422136 Gallus gallus
492123 Canis lupus familiaris
535844 Bos taurus
702345 Macaca mulatta
777716 Danio rerio
100021521 Monodelphis domestica
100059144 Equus caballus
100087165 Ornithorhynchus anatinus
100125214 Xenopus (Silurana) tropicalis
100172875 Pongo abelii
100346052 Oryctolagus cuniculus
100415106 Callithrix jacchus
100476961 Ailuropoda melanoleuca
100524726 Sus scrofa
100543414 Meleagris gallopavo
100563751 Anolis carolinensis
100603753 Nomascus leucogenys
4952 Homo sapiens
320634 Mus musculus
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