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OLFM4 was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. Additionally we are shipping Olfactomedin 4 Antibodies (68) and Olfactomedin 4 Kits (33) and many more products for this protein.
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Human OLFM4 Protein expressed in Human Cells - ABIN2004463
Zhang, Liu, Tang, Chen, Wang, Pack, Zhuang, Rodgers: Identification and characterization of a novel member of olfactomedin-related protein family, hGC-1, expressed during myeloid lineage development. in Gene 2002
Show all 4 Pubmed References
OLFM4 has an important role in the regulation of intestinal inflammation and tumorigenesis, and could be a potential therapeutic target for intestinal malignant tumors. Unlike the human colonic epithelium, the mouse colonic epithelium does not express OLFM4, but nevertheless, systemic OLFM4 deletion promotes colon tumorigenesis and that loss from mucosal neutrophils may have a role to play.
Olfactomedin-4 identifies a subpopulation of neutrophils in patients with septic shock, and those with a high percentage of olfactomedin-4+ neutrophils are at higher risk for greater organ failure burden and death. Olfactomedin-4 might serve as a marker of a pathogenic neutrophil subset in patients with septic shock
OLFM4 is proved to as a functional target for miR (show MLXIP Proteins)-590.
Olfactomedin 4 is a novel tumor marker for triple-negative breast cancer for predicting and prognosis.
OLFM4 is downregulated by miR (show MLXIP Proteins)-486-5p, which contributes to ovarian cancer tumorigenesis. Conversely, estrogen receptor (show ESR1 Proteins) signaling downregulates miR (show MLXIP Proteins)-486-5p and upregulates OLFM4 expression, slowing the development and progression of ovarian cancer.
Data show that olfactomedin 4 (OLFM4) is highly expressed in proliferating benign epithelial cells and in some carcinoma cells.
olfactomedin 4 appears to play a critical role in regulating progression of prostate cancer, and has potential as a new biomarker for prostate cancer.
Study demonstrates that epigenetic silencing of OLFM4 enhances gastric cancer cell invasion via activation of FAK (show PTK2 Proteins) signaling.
suppression of OLFM4 expression may be a promising strategy in the development of novel cancer therapeutic drugs
Patients with an OLFM4 gene expression level above -7.5 were 6 times more likely to develop severe disease, after correction for age at hospitalization and gestational age.
OLFM4 may function as a tumor suppressor and an anti-metastatic gene during tumor progression
Olfm4 deletion can successfully enhance immune defense against S. aureus, but not A. fumigatus, in chronic granulomatous disease mice.
OLFM4 exerts considerable influence on the host defense against H. pylori infection acting through NOD1 (show NOD1 Proteins) and NOD2 mediated NF-kappaB (show NFKB1 Proteins) activation and subsequent cytokines and chemokines production, which in turn inhibit host immune response.
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion.
, G-CSF-stimulated clone 1 protein
, antiapoptotic protein GW112
, PU.1 difference product 4