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Oligodendrocyte Lineage Transcription Factor 2 Proteins (OLIG2)

OLIG2 encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. Additionally we are shipping OLIG2 Antibodies (106) and OLIG2 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OLIG2 10215 Q13516
OLIG2 304103  
OLIG2 50913 Q9EQW6
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Top OLIG2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,790.33
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OLIG2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)
Mouse (Murine)

More Proteins for Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) Interaction Partners

Human Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. Olig2 was positive in 5 out of 44 ependymomas (11%) and 50 out of 54 (93%) non-ependymal tumors

  2. The present study is the first to verify the associations of SNPs rs762178, rs1059004, and rs9653711 of the OLIG2 gene with OCD in a Chinese Han population. Thus, OLIG2 might serve as a potential target for OCD treatment

  3. The results demonstrate that the expression of Olig2 in dental pulp stem cells reduces the expression of stem cell markers and induces the development of oligodendrocyte progenitors.

  4. High Olig2 expression is associated with oligodendrogliomas.

  5. OLIG2 is the most specific GSC (show GSC Proteins) marker.

  6. Our study suggests that CGT (show UGT8 Proteins) expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2 (show Nkx2-2 Proteins), providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners.

  7. Authors investigated the role of Pten in these two critical cellular compartments in adult and developing brains using methods for activation or suppression of PI3K (show PIK3CA Proteins) signaling in glial and neuronal progenitors expressing Olig2.

  8. LGR5 (show LGR5 Proteins) expression may be functionally correlated with the neurogenic competence, and be regulated by OLIG2 in stem-like cells in glioblastoma.

  9. We found that the risk allele OLIG2 (A) was associated with reduced white matter integrity in the corona radiata bilaterally

  10. Olig2-positive cells in glioneuronal tumors, and some of them also exhibited neuronal features

Zebrafish Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. these data raise the possibility that cells expressing olig2 are intermediate targets that help guide facial motor neuron migration.

  2. Study detected at least five different classes of olig2-positive cells in the telencephalon of the adult zebrafish.

  3. By cooperating with Shh (show SHH Proteins), FGF-receptor (show FGFR2 Proteins) signalling controls the expression of olig2, a patterning gene essential for the specification of somatic motoneurons and oligodendrocytes.

  4. Loss of olig2 function prevents primary motor neuron and oligodendrocyte development, whereas olig2 overexpression promotes formation of excess primary motor neurons and oligodendrocytes.

  5. Olig2 is required for repression of iro3 (show IRX3 Proteins) expression in the progenitor domain of ventral spinal cord

  6. data indicate that Hedgehog (show SHH Proteins) & Wnt (show WNT2 Proteins) work in opposition across the dorsoventral axis of the cerebellum to regulate formation of olig2(+) neurons; we propose that Hedgehog (show SHH Proteins) limits the range of Wnt (show WNT2 Proteins) signaling, which is necessary for olig2(+) neuron development

  7. commitment of basal diencephalic DA neurons is regulated by the combined action of the neural protein Olig2 and its downstream neuronal specific effector Sim1

Mouse (Murine) Oligodendrocyte Lineage Transcription Factor 2 (OLIG2) interaction partners

  1. This study suggests that Olig2 misexpression in neural stem cells elicits neurogenesis defects and neuronal cell death, which may contribute to developmental disorders including Down syndrome

  2. OLIG2 is a multifunctional regulator of neural stem cell self-renewal

  3. Olig2 expression is localized to the cochleovestibular ganglia from E12.5 through E14.5

  4. Olig2 overexpression accelerates the differentiation of mouse embryonic stem cells into oligodendrocyte progenitor cells in vitro.

  5. This study demonstrated that that OLIG2 overexpression in oligodendrocyte progenitor cells might be a possible therapeutic mechanism for enhancing myelin repair.

  6. Results from expression pattern suggests that Olig2 may have an important role in the early stage of Purkinje cell development.

  7. Prox1 (show C16orf35 Proteins) controls binary fate decisions between motor neurons and V2 interneurons in progenitor cells via direct repression of Olig2 gene regulatory elements

  8. Phosphorylated Olig2 is preferentially localized to a transcriptionally active compartment for regulation of gene expression.

  9. Olig2 is involved in correct formation of the prethalamus.

  10. Notch (show NOTCH1 Proteins) signaling might promote proliferation and differentiation of reactive astrocytes through regulation of nucleo-cytoplasmic translocation of Olig2.

OLIG2 Protein Profile

Protein Summary

This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14\;21)(q11.2\;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome.

Gene names and symbols associated with OLIG2

  • oligodendrocyte transcription factor 4 (olig4)
  • oligodendrocyte lineage transcription factor 2 (OLIG2)
  • oligodendrocyte lineage transcription factor 2 (LOC100347256)
  • oligodendrocyte lineage transcription factor 2 (Olig2)
  • oligodendrocyte lineage transcription factor 2 (olig2)
  • oligodendrocyte transcription factor 2 (Olig2)
  • oligodendrocyte transcription factor 3 (OLIG3)
  • AI604895 protein
  • Bhlhb1 protein
  • bHLHe19 protein
  • MGC89336 protein
  • Olg-2 protein
  • OLIG2 protein
  • olig3.2 protein
  • Oligo2 protein
  • PRKCBP2 protein
  • RACK17 protein
  • RK17 protein
  • wu:fc64g09 protein

Protein level used designations for OLIG2

oligodendrocyte transcription factor 4 , oligodendrocyte transcription factor 3 , oligodendrocyte lineage transcription factor 2 , basic domain, helix-loop-helix protein, class B, 1 , class B basic helix-loop-helix protein 1 , class E basic helix-loop-helix protein 19 , human protein kinase C-binding protein RACK17 , oligodendrocyte transcription factor 2 , oligodendrocyte-specific bHLH transcription factor 2 , protein kinase C-binding protein 2 , bHLH transcription factor Olig2 , oligo2

GENE ID SPECIES
734024 Xenopus (Silurana) tropicalis
749928 Pan troglodytes
100137242 Papio anubis
100347256 Oryctolagus cuniculus
10215 Homo sapiens
539695 Bos taurus
304103 Rattus norvegicus
325288 Danio rerio
50913 Mus musculus
428612 Gallus gallus
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