anti-Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Antibodies

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009. Additionally we are shipping Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Proteins (13) and Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OBFC1 79991 Q9H668
OBFC1 108689 Q8K2X3
OBFC1 294025 Q6AYD2
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Top anti-Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-OBFC1 Antibody Titration: 1.0 ug/ml Positive Control: Fetal Heart 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of OBFC1 Antibody (C-term) in A549 cell line lysates (35ug/lane). This demonstrates the OBFC1 antibody detected the OBFC1 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated WB OBFC1 monoclonal antibody (M01), clone 3G12-1B7 Western Blot analysis of OBFC1 expression in Jurkat. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated FACS, IF, WB HEK293T cells transfected with either RC200778 overexpress plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-OBFC1 antibody (ABIN2454844), and then analyzed by flow cytometry. Anti-OBFC1 mouse monoclonal antibody (ABIN2454844) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY OBFC1 (RC200778). 100 μL Log in to see 2 to 3 Days
$423.50
Details
Human Mouse Un-conjugated ELISA, WB OBFC1 monoclonal antibody (M01), clone 3G12-1B7 Western Blot analysis of OBFC1 expression in Jurkat . Western Blot detection against Immunogen (66.22 KDa) . 100 μg Log in to see 11 to 12 Days
$430.00
Details
Human Rabbit Un-conjugated WB OBFC1 Antibody (C-term)  western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the OBFC1 antibody detected the OBFC1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated FACS, ICC, IF, WB Immunocytochemistry/Immunofluorescence: OBFC1 Antibody (2E4) [NBP2-01006] Staining of COS7 cells transiently transfected by pCMV6-ENTRY OBFC1. Western Blot: OBFC1 Antibody (2E4) [NBP2-01006] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY OBFC1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-OBFC1. 0.1 mL Log in to see 8 to 11 Days
$447.56
Details
Human Mouse Un-conjugated FACS, IF, WB 100 μL Log in to see 7 to 9 Days
$529.83
Details
Human Rabbit Un-conjugated IF, IP, WB Immunoprecipitation of OBFC1 transfected lysate using anti-OBFC1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with OBFC1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of OBFC1 expression in transfected 293T cell line by OBFC1 MaxPab polyclonal antibody.<br><br>Lane 1: OBFC1 transfected lysate(42.1 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μL Log in to see 11 to 12 Days
$418.57
Details

OBFC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human
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,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Antibodies

  1. Yeast (Saccharomyces cerevisiae) Polyclonal OBFC1 Primary Antibody for IHC - ABIN967111 : Grandin, Reed, Charbonneau: Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13. in Genes & development 1997 (PubMed)
    Show all 5 Pubmed References

  2. Yeast (Saccharomyces cerevisiae) Polyclonal OBFC1 Primary Antibody for - ABIN967112 : Coster, Jonniaux, Goffeau: Analysis of a 32.8 kb segment of yeast chromosome IV reveals 21 open reading frames, including TPS2, PPH3, RAD55, SED1, PDC2, AFR1, SSS1, SLU7 and a tRNA for arginine. in Yeast (Chichester, England) 1995 (PubMed)
    Show all 5 Pubmed References

  3. Human Monoclonal OBFC1 Primary Antibody for ELISA, WB - ABIN566413 : Wan, Qin, Songyang, Liu: OB fold-containing protein 1 (OBFC1), a human homolog of yeast Stn1, associates with TPP1 and is implicated in telomere length regulation. in The Journal of biological chemistry 2009 (PubMed)

More Antibodies against Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Interaction Partners

Human Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. CTC1 (show CTC1 Antibodies)/STN1 (show STON1 Antibodies)/TEN1 (CST (show GAL3ST1 Antibodies)) deficiency diminishes HU-induced RAD51 (show RAD51 Antibodies) foci formation.

  2. STN1 (show STON1 Antibodies)-POLA2 (show POLA2 Antibodies) interaction provides a basis for primase-polymerase alpha stimulation by human STN1 (show STON1 Antibodies). A disease-causing mutation in human STN1 (show STON1 Antibodies) engenders a selective defect in POLA2 (show POLA2 Antibodies)-binding.

  3. The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.

  4. TERT-mediated G-strand extension and Ctc1-Stn1-Ten1-mediated C-strand fill-in are equally important for telomere length maintenance.

  5. Mutations in STN1 (show STON1 Antibodies) cause Coats plus syndrome and are associated with genomic and telomere defects.

  6. The mammalian CST (show GAL3ST1 Antibodies) (CTC1 (show CTC1 Antibodies)-STN1 (show STON1 Antibodies)-TEN1) complex is directly involved at several stages of telomere end formation and CST (show GAL3ST1 Antibodies) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.

  7. we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1 (show CTC1 Antibodies)). Interestingly, we observed that genetic variation does not account for LTL at birth

  8. A 2-SNP OBFC1 haplotype was associated with higher risk of CHD (show CHDH Antibodies), and a 3-SNP TERC haplotype was associated with both higher risk of CHD (show CHDH Antibodies) and T2D.

  9. The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.

  10. the requirement for STN1 (show STON1 Antibodies)/CST (show GAL3ST1 Antibodies) in telomere duplex replication correlates with increasing telomere length and replication stress.

Mouse (Murine) Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.

Arabidopsis thaliana Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) interaction partners

  1. STN1 plays a genome-wide role in DNA replication and telomere stability.

  2. POT1a promotes an extendable telomere state via contacts with the telomerase RNP as well as STN1 and CTC1, while TEN1 opposes these functions.

  3. findings indicate that ATR and CST (CTC1/STN1/TEN1) act synergistically to maintain genome integrity and telomere length homeostasis

  4. AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)

  5. CTC1 (show CTC1 Antibodies) participates in telomere maintenance in diverse species and that a CST (show GAL3ST1 Antibodies)-like complex is required for telomere integrity in multicellular organisms.

Oligonucleotide/oligosaccharide-Binding Fold Containing 1 (OBFC1) Antigen Profile

Protein Summary

OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009

Gene names and symbols associated with OBFC1

  • oligonucleotide/oligosaccharide-binding fold containing 1 (OBFC1) antibody
  • oligonucleotide/oligosaccharide-binding fold containing 1 (Obfc1) antibody
  • oligonucleotide/oligosaccharide-binding fold containing 1 (obfc1) antibody
  • STN1-like protein (STN1) antibody
  • 0610009H20Rik antibody
  • 2310057J23Rik antibody
  • AAF-44 antibody
  • AAF44 antibody
  • AI413458 antibody
  • ATSTN1 antibody
  • bA541N10.2 antibody
  • F10K1.17 antibody
  • F10K1_17 antibody
  • RP11-541N10.2 antibody
  • RPA-32 antibody
  • STN1 antibody
  • zgc:64174 antibody

Protein level used designations for OBFC1

CST complex subunit STN1 , alpha accessory factor 44 , oligonucleotide/oligosaccharide-binding fold-containing protein 1 , replication protein A 32 kDa subunit , suppressor of cdc thirteen homolog , alpha-accessory factor of 44 kDa

GENE ID SPECIES
79991 Homo sapiens
108689 Mus musculus
294025 Rattus norvegicus
514213 Bos taurus
393360 Danio rerio
837223 Arabidopsis thaliana
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