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OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009 [PubMed 19119139]). Additionally we are shipping Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Antibodies (48) and Oligonucleotide/oligosaccharide-Binding Fold Containing 1 Kits (5) and many more products for this protein.
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STN1 (show STON1 Proteins)-POLA2 (show POLA2 Proteins) interaction provides a basis for primase-polymerase alpha stimulation by human STN1 (show STON1 Proteins). A disease-causing mutation in human STN1 (show STON1 Proteins) engenders a selective defect in POLA2 (show POLA2 Proteins)-binding.
The findings imply that theCTC1/STN1/TEN1 complex(CST )complex plays an important role in regulating telomere maintenance in alternative-lengthening of telomeres(ALT) cells.
TERT (show TERT Proteins)-mediated G-strand extension and Ctc1-Stn1 (show STON1 Proteins)-Ten1 (show TEN1 Proteins)-mediated C-strand fill-in are equally important for telomere length maintenance.
Mutations in STN1 (show STON1 Proteins) cause Coats plus syndrome and are associated with genomic and telomere defects.
The mammalian CST (show GAL3ST1 Proteins) (CTC1-STN1 (show STON1 Proteins)-TEN1 (show TEN1 Proteins)) complex is directly involved at several stages of telomere end formation and CST (show GAL3ST1 Proteins) seems to play critical roles in coordinating telomerase elongation and fill-in synthesis to telomere replication.
we explored two SNPs in genes associated either with telomere biology (OBFC1) or with LTL (OBCF1 and CTC1). Interestingly, we observed that genetic variation does not account for LTL at birth
A 2-SNP OBFC1 haplotype was associated with higher risk of CHD (show CHDH Proteins), and a 3-SNP TERC haplotype was associated with both higher risk of CHD (show CHDH Proteins) and T2D.
The Stn1 deficiency leads to persistent and elevated association of DNA polymerase alpha to telomeres, suggesting that Stn1 may modulate the DNA synthesis activity of polalpha rather than controlling the loading of polalpha to telomeres.
the requirement for STN1 (show STON1 Proteins)/CST (show GAL3ST1 Proteins) in telomere duplex replication correlates with increasing telomere length and replication stress.
CTC1-STN1 (show STON1 Proteins)-TEN1 (show TEN1 Proteins) complex rescues stalled replication forks during conditions of replication stress, such as those found at natural replication barriers, likely by facilitating dormant origin firing
OBFC1 is identical to the previously described 44 kDa subunit of DNA-pol-alpha/primase associated factor (AAF) which increases polymerase-alpha/primase template affinity and stimulate both DNA primase and polymerase-alpha activities in vitro.
STN1 plays a genome-wide role in DNA replication and telomere stability.
POT1a (show POT1 Proteins) promotes an extendable telomere state via contacts with the telomerase RNP (show RNPC3 Proteins) as well as STN1 and CTC1, while TEN1 (show TEN1 Proteins) opposes these functions.
findings indicate that ATR and CST (show GAL3ST1 Proteins) (CTC1/STN1/TEN1 (show TEN1 Proteins)) act synergistically to maintain genome integrity and telomere length homeostasis
AtSTN1 is a crucial component of the protective telomere cap in Arabidopsis, and likely in other multicellular eukaryotes. (AtSTN1)
CTC1 participates in telomere maintenance in diverse species and that a CST (show GAL3ST1 Proteins)-like complex is required for telomere integrity in multicellular organisms.
OBFC1 and C17ORF68 (MIM 613129) are subunits of an alpha accessory factor (AAF) that stimulates the activity of DNA polymerase-alpha-primase (see MIM 176636), the enzyme that initiates DNA replication (Casteel et al., 2009
CST complex subunit STN1
, alpha accessory factor 44
, oligonucleotide/oligosaccharide-binding fold-containing protein 1
, replication protein A 32 kDa subunit
, suppressor of cdc thirteen homolog
, alpha-accessory factor of 44 kDa