Oligophrenin 1 Proteins (OPHN1)

OPHN1 encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Additionally we are shipping Oligophrenin 1 Antibodies (16) and Oligophrenin 1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OPHN1 4983 O60890
OPHN1 94190 Q99J31
OPHN1 312108 P0CAX5
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Top Oligophrenin 1 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$11,073.30
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$605.00
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HOST_Escherichia coli (E. coli) Rat T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$605.00
Details

OPHN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Oligophrenin 1 (OPHN1) Interaction Partners

Human Oligophrenin 1 (OPHN1) interaction partners

  1. Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment

  2. Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase (show ROCK1 Proteins) inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets.

  3. we reported on the first male patient carrying an OPHN1 mutation with IQ score within the normal limits. This observation expands the phenotypic spectrum of OPHN1 mutations.

  4. A neuronal stem cell-based model for the treatment of OPHN1 syndrome and other neurological disorders due to ROCK dysfunction.

  5. results suggest that oligophrenin-1 is involved in tumor progression in prostate cancer

  6. This is the first description of an in-frame deletion within the BAR domain of OPHN1 and could provide new insights into the role of this domain in relation to brain and cognitive development or function.

  7. Our results demonstrate that multiple post-transcriptional events occur on OPHN1, a gene playing an important role in brain function and development.

  8. In response to GPVI (show GP6 Proteins) stimulation, OPHN1 becomes phosphorylated at Tyr370 and plays a role in the formation of filopodia during platelet spreading on collagen.

  9. Several genes expressed at exceptionally high levels were identified associated with early oocyte development, TMEFF2 (show TMEFF2 Proteins), the Rho-GTPase-activating protein (show STARD13 Proteins) oligophrenin 1 (OPHN1) and the mitochondrial-encoded ATPase6 (ATP6 (show MT-ATP6 Proteins)).

  10. This mutation determines the production of a mutant oligophrenin 1 protein with 16 extra amino acids inserted in-frame in the N-terminal BAR (Bin1 (show BIN1 Proteins)/amphiphysin (show AMPH Proteins)/Rvs167) domain. (oligophrenin 1 protein )

Mouse (Murine) Oligophrenin 1 (OPHN1) interaction partners

  1. Here, we report that chronic treatment in adult mouse with Fasudil, is able to counteract vertical and horizontal hyperactivities, restores recognition memory and limits the brain ventricular dilatation observed in Ophn1(-)(/y) However, deficits in working and spatial memories are partially or not rescued by the treatment

  2. Furthermore, we found that olfactory behaviour was perturbed in OPHN1 ko mice. Chronic treatment with a Rho kinase (show ROCK2 Proteins) inhibitor rescued most of the defects of the newly generated neurons. Altogether, our data indicated that OPHN1 plays a key role in regulating the number, morphology and function of adult-born inhibitory interneurons and contributed to identify potential therapeutic targets.

  3. OPHN1 mediated regulation of RhoA (show RHOA Proteins), Rac1 and Cdc42 (show CDC42 Proteins) is crucial for the preservation of cardiac function after myocardial injury.

  4. Identify OPHN1 as an important regulator of platelet cytoskeletal reorganization and thrombus formation.

  5. OPHN1 is a bifunctional protein that is able, through distinct mechanisms, to regulate and most likely link exocytosis to compensatory endocytosis in chromaffin cells.

  6. OPHN1 is a powerful regulator of Rho GTPase (show RACGAP1 Proteins) activity in platelets that is critical for the reorganization of the cytoskeleton, which is a major process required for stable platelet adhesion and thrombus formation to occur.

  7. Ophn1 is involved in processes of normal retinal vessel function during adulthood.

  8. our data establish a role for rapid OPHN1 synthesis in mGluR (show GRM8 Proteins) long-term depression.

  9. The results of this study indicated the presence of a circadian oscillator in the hippocampus, involving the clock gene Bmal1 (show ARNTL Proteins) (also known as Arntl (show ARNTL Proteins)), that is modulated by Rev-erbalpha (show NR1D1 Proteins) and requires oligophrenin-1 for normal oscillation.

  10. Oligophrenin-1 is expressed in developing CNS areas that evince synaptic plasticity. OPHN1 is expressed in both glial and neuronal cells, where it colocalizes with actin at the tip of growing neurites.

Cow (Bovine) Oligophrenin 1 (OPHN1) interaction partners

  1. OPHN1 is a bifunctional protein that is able, through distinct mechanisms, to regulate and most likely link exocytosis to compensatory endocytosis in chromaffin cells.

Oligophrenin 1 (OPHN1) Protein Profile

Protein Summary

This gene encodes a Rho-GTPase-activating protein that promotes GTP hydrolysis of Rho subfamily members. Rho proteins are important mediators of intracellular signal transduction, which affects cell migration and cell morphogenesis. Mutations in this gene are responsible for OPHN1-related X-linked mental retardation with cerebellar hypoplasia and distinctive facial dysmorhphism.

Gene names and symbols associated with Oligophrenin 1 Proteins (OPHN1)

  • oligophrenin-1-like (LOC100065450)
  • oligophrenin 1 (ophn1)
  • oligophrenin 1 (OPHN1)
  • oligophrenin 1 (Tsp_13482)
  • oligophrenin 1 (Ophn1)
  • oligophrenin-1-like (LOC525644)
  • ARHGAP41 protein
  • C130037N19Rik protein
  • MGC68856 protein
  • MRX60 protein
  • OPHN1 protein
  • Opn1 protein
  • zgc:92603 protein

Protein level used designations for Oligophrenin 1 Proteins (OPHN1)

oligophrenin 1 , oligophrenin-1 , mental retardation, X-linked 60 , oligophrenin-1, Rho-GTPase activating protein

GENE ID SPECIES
100065450 Equus caballus
379682 Xenopus laevis
422162 Gallus gallus
436982 Danio rerio
703141 Macaca mulatta
710787 Macaca mulatta
779935 Xenopus (Silurana) tropicalis
10901254 Trichinella spiralis
100379222 Cavia porcellus
100554128 Anolis carolinensis
4983 Homo sapiens
94190 Mus musculus
312108 Rattus norvegicus
607363 Canis lupus familiaris
449628 Pan troglodytes
525644 Bos taurus
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