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Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).. Additionally we are shipping OIP5 Proteins (4) and many more products for this protein.
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These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) growth and metastasis and that miR (show MLXIP Antibodies)-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC (show FAM126A Antibodies).
the Mis18 complex contains dual CENP-C (show CENPC1 Antibodies) recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A (show CENPA Antibodies) deposition
OIP5 over-expression inhibited hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1 (show NOTCH1 Antibodies), which was a core oncogene (show RAB1A Antibodies) in promoting breast cancer progression.
Stable binding of Mis18alpha (show MIS18A Antibodies)-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A (show CENPA Antibodies) deposition.
Over-expression of OIP5 was observed in breast tumors.
Mis18beta binds with and specifies the centromere localization of HJURP (show HJURP Antibodies).
this study showed betaTrCP (show BTRC Antibodies)-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase.
expression of AURKC (show AURKC Antibodies), OIP5, PIWIL2 (show PIWIL2 Antibodies) and TAF7L (show TAF7L Antibodies) differed between patients with Acute myeloid leukemia (show BCL11A Antibodies), myelodysplastic syndrome and healthy controls in a gender-dependent manner
OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients
These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells.
Increase of Oip5 may associate with development of obesity.
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).
, Opa interacting protein 5
, LAP2alpha interactor-25
, MIS18 kinetochore protein homolog B
, cancer/testis antigen 86
, opa-interacting protein 5
, opa-interacting protein 5 homolog