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Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Additionally we are shipping OPN5 Antibodies (59) and OPN5 Proteins (3) and many more products for this protein.
A novel opsin (show RHO ELISA Kits) isoform, Opn5m2, exhibits UV light-sensitivity when binding to 11-cis (show CISH ELISA Kits)-retinal. It displays distinct molecular properties and broad distribution in the retina and brain.
Opn5m proteins in zebrafish, Xenopus tropicalis, mouse, and human are also UV-sensitive pigments.
Expression of the hNP (show KLK8 ELISA Kits) gene on the mRNA level, evaluated based on peripheral blood, is significantly higher in the patients with MRD than in the healthy subjects.
Data indicate that opsin5 (OPN5) photoreceptor mediates light-induced Ca(2 (show CA2 ELISA Kits)+) response.
It dissects a schizophrenic susceptibility gene, NRG1 (show NRG1 ELISA Kits).
Opn5m may work exclusively as a short wavelength sensor in the brain as well as in the retina with the assistance of an 11 (show DCAF7 ELISA Kits)-cis (show CISH ELISA Kits)-retinal-supplying system.
UV photoreceptor in human beings OPN5 triggers a UV-sensitive Gi-mediated signaling pathway in the mammalian tissues.
Genetic variation of the hNP (show KLK8 ELISA Kits) gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence.
These results suggest that the neuropsin (show KLK8 ELISA Kits)-NRG1 (show NRG1 ELISA Kits) signaling system has a role in pathological processes underlying temporal lobe epilepsy by regulating the activity of parvalbumin (show PVALB ELISA Kits)-expressing interneurons, and that neuropsin (show KLK8 ELISA Kits) regulates E/I balance and gamma oscillations through NRG1 (show NRG1 ELISA Kits)-ErbB4 (show ERBB4 ELISA Kits) signaling toward parvalbumin (show PVALB ELISA Kits)-expressing interneurons.
we demonstrate that neuropsin (show KLK8 ELISA Kits) inactivation protects against the impairment of hippocampal functions and the depressive-like behaviour induced by chronic stress or high levels of corticosterone. Consequently, we suggest neuropsin (show KLK8 ELISA Kits) is a potential target for clinical interventions for the management of stress disorders
Age-dependent variation in different brain regions were found in neuropsin (show KLK8 ELISA Kits) expression.
mouse corneal circadian rhythm is also photoentrainable ex vivo, and this photoentrainment likewise requires OPN5. Our findings reveal a light-sensing function for mammalian OPN5, until now an orphan opsin (show RHO ELISA Kits)
Thus, ErbB4 (show ERBB4 ELISA Kits) signaling induced by neuropsin (show KLK8 ELISA Kits)-dependent processing of NRG-1 (show NRG1 ELISA Kits) contributes to the modulation of synaptic plasticity via regulation of GABAergic transmission.
OPN5 was capable of activating heterotrimeric G protein Gi in a UV-dependent manner
Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This opsin gene is expressed in the eye, brain, testes, and spinal cord. This gene belongs to the seven-exon subfamily of mammalian opsin genes that includes peropsin (RRH) and retinal G protein coupled receptor (RGR). Like these other seven-exon opsin genes, this family member may encode a protein with photoisomerase activity. Alternative splicing results in multiple transcript variants.
, opsin 5
, opsin 5-like
, G-protein coupled receptor 136
, transmembrane protein 13
, G protein-coupled receptor 136
, G-protein coupled receptor PGR12