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Optic Atrophy 1 (Autosomal Dominant) (OPA1) ELISA Kits

OPA1 product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. Additionally we are shipping OPA1 Antibodies (43) and OPA1 Proteins (9) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse OPA1 OPA1 74143 P58281
Anti-Rat OPA1 OPA1 171116 Q2TA68
Anti-Human OPA1 OPA1 4976 O60313
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More ELISA Kits for OPA1 Interaction Partners

Mouse (Murine) Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. Whereas Parkin (show PARK2 ELISA Kits) has been reported to positively regulate the expression of OPA1 (show MED12 ELISA Kits) through NEMO (show IKBKG ELISA Kits), herein we found that PARK2 (show PARK2 ELISA Kits) overexpression did not modify the expression of OPA1 (show MED12 ELISA Kits).

  2. stress-induced OMA1 activation and guanosine triphosphatase OPA1 (show MED12 ELISA Kits) cleavage limit mitochondrial fusion and promote neuronal death

  3. Data suggest that in a mouse model of neonatal hypoxic-ischemic brain injury, the expression of mitochondrial shaping proteins, such as OPA1 (show MED12 ELISA Kits) and Yme1L (show YME1L1 ELISA Kits), are altered; in vitro and in vivo, OPA1 (show MED12 ELISA Kits) is cleaved to shorter forms and Yme1L (show YME1L1 ELISA Kits) expression is reduced.

  4. results indicate that the OPA1 (show MED12 ELISA Kits)-dependent cristae remodeling pathway is a fundamental, targetable determinant of tissue damage in vivo.

  5. cristae shape amelioration by controlled Opa1 (show MED12 ELISA Kits) overexpression improves two mouse models of mitochondrial disease.

  6. unprocessed OPA1 is sufficient to maintain heart function, OMA1 is a critical regulator of cardiomyocyte survival, and mitochondrial morphology and cardiac metabolism are intimately linked.

  7. Data suggest that mitochondrial fusion and fission events are regulated by four GTPases: OPA1 (show MED12 ELISA Kits), Drp1 (dynamin 1-like protein (show DNM1L ELISA Kits)), and Mfn1 (show MFN1 ELISA Kits)/2 (mitofusin 1 (show MFN1 ELISA Kits) and 2). [REVIEW]

  8. Photoresponsive RGCs are protected against cell death due to the Opa1 (show MED12 ELISA Kits) mutation, but not by melanopsin (show OPN4 ELISA Kits) expression itself.

  9. Results suggest that Mfn2 (show MFN2 ELISA Kits) and OPA1 (show MED12 ELISA Kits) are upregulated during bone marrow progenitor differentiation and promote the migration of immature dendritic cells by regulating the expression of CCR7 (show CCR7 ELISA Kits).

  10. Reactive oxygen species might affect MyHC content by modulating OPA1 (show MED12 ELISA Kits) cleavage in muscle degeneration.

Human Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. OPA1 variants confer risk of leprosy in Chinese Han population and may affect OPA1 expression, mitochondrial function and antimicrobial pathways.

  2. Genotype-phenotype heterogeneity in OPA1 autosomal-dominant optic atrophy (ADOA). is evident when inner retinal atrophy is examined as a function of age.

  3. Heterozygous mutation in OPA1 disrupts the GTPase (show RACGAP1 ELISA Kits) domain of OPA1 and is associated with phenotypically variable ADOA Plus.

  4. Identification of copy number variation in the gene for autosomal dominant optic atrophy, OPA1, in a Chinese pedigree

  5. Data show that OPA1 physiological levels are important in cardiovascular health by maintaining mitochondrial shape and respiratory function, while its down-regulation is associated with cardiovascular disease. [review]

  6. increased percentage of apoptotic cells in autosomal dominant optic atrophy patients compared to controls; suggests susceptibility of ADOA cells to oxidative stress and correlation between OPA1 protein dysfunctions and morphological-functional alterations to mitochondria; also results imply sensitivity of mutated protein to free radical damage

  7. Distributed abnormalities of diffusivity indexes might reflect abnormal intracellular mitochondrial morphology as well as alteration of protein levels due to OPA1 mutations.

  8. A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family.

  9. Two heterozygous OPA1 missense mutations affecting highly conserved amino acid positions (p.G488R, p.A495V) were associated with chronic progressive external ophthalmoplegia, parkinsonism, and dementia in two Italian families.

  10. OPA1 mutations induced mitochondrial fragmentation, uncoupled mitochondrial respiration, and elicited dysfunctional bioenergetics.

Zebrafish Optic Atrophy 1 (Autosomal Dominant) (OPA1) interaction partners

  1. Opa1 is required for proper mitochondrial metabolism in early development

OPA1 Antigen Profile

Antigen Summary

This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with OPA1

  • optic atrophy 1 (Opa1) antibody
  • optic atrophy 1 (autosomal dominant) (OPA1) antibody
  • optic atrophy 1 (human) (opa1) antibody
  • 1200011N24Rik antibody
  • AI225888 antibody
  • AI847218 antibody
  • fk62d06 antibody
  • largeG antibody
  • lilr3 antibody
  • MGM1 antibody
  • mKIAA0567 antibody
  • NPG antibody
  • NTG antibody
  • wu:fb77a10 antibody
  • wu:fk62d06 antibody
  • zgc:92092 antibody

Protein level used designations for OPA1

dynamin-like 120 kDa protein, mitochondrial , large GTP-binding protein , largeG , optic atrophy 1 homolog , optic atrophy protein 1 homolog , RN protein , optic atrophy 1 (autosomal dominant) , optic atrophy 1-like protein , dynamin-like guanosine triphosphatase , mitochondrial dynamin-like GTPase , optic atrophy protein 1

74143 Mus musculus
171116 Rattus norvegicus
4976 Homo sapiens
424900 Gallus gallus
477129 Canis lupus familiaris
524142 Bos taurus
100172619 Pongo abelii
492332 Danio rerio
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