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Binds collagen fibrils (By similarity).. Additionally we are shipping OPTC Antibodies (18) and OPTC Kits (8) and many more products for this protein.
Showing 5 out of 5 products:
opticin binds to collagen and thereby competitively inhibits endothelial cell interactions with collagen via alpha(1)beta(1) and alpha(2)beta(1) integrins, thereby preventing the strong adhesion that is required for proangiogenic signaling via these integrins.
VEGF (show VEGFA Proteins) and hypoxia could decrease opticin protein levels in the human retinal pigment epithelium secretome, and that opticin may be an enzymatic substrate for MMP-2 (show MMP2 Proteins).
localization in the human eye and genetic screen of opticin
OPTC is a candidate gene for primary open-angle glaucoma
OPTC and EPYC (show EPYC Proteins) are unlikely to play a major role in high myopia.
opticin is a stable dimer in solution [OPTC, opticin]
Binds collagen fibrils (By similarity).
, small leucine-rich repeat protein
, dermatan sulfate proteoglycan 3