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anti-Optineurin (OPTN) Antibodies

OPTN encodes the coiled-coil containing protein optineurin. Additionally we are shipping Optineurin Kits (11) and Optineurin Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OPTN 10133 Q96CV9
OPTN 246294 Q8R5M4
OPTN 71648 Q8K3K8
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Top anti-Optineurin Antibodies at antibodies-online.com

Showing 10 out of 89 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: MCF7 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-OPTN Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: Hela cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated ICC, IF, IP, IHC (p), WB IP Image Optineurin antibody immunoprecipitates Optineurin protein in IP experiments. IP samples: HepG2 whole cell extract A. Control with 4 μg of preimmune Rabbit IgG B. Immunoprecipitation of Optineurin protein by 4 μg Optineurin antibody , 7.5 % SDS-PAGE The immunoprecipitated Optineurin protein was detected by Optineurin antibody , diluted at 1:500. [EasyBlot anti-rabbit IgG  was used as a secondary reagent] WB Image Sample(30 ug whole cell lysate) A:A431, B:H1299 C:Hep G2 , 10% SDS PAGE antibody diluted at 1:2000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB OPTN Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the OPTN antibody detected the OPTN protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Human Adrenal (formalin-fixed, paraffin-embedded) stained with OPTN antibody ABIN290410 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 125 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- Optineurin Picoband antibody, IHC(P) IHC(P): Human Placenta Tissue 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF, WB Figure 1. Immunofluorescence analysis of Paraformaldehyde-Fixed HeLa using AP20023PU-N Optineurin/HIP7 antibody at 1/200 dilution. Figure 2. Western Blot using Optineurin antibody (at 1/2000 dilution): Sample(30 µg whole cell lysate) A: A431 B: H1299 C: HepG2 10% SDS PAGE. 0.1 mL Log in to see 6 to 8 Days
$401.50
Details

OPTN Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Optineurin Antibodies

  1. Cow (Bovine) Polyclonal OPTN Primary Antibody for WB - ABIN2779546 : Morton, Hesson, Peggie, Cohen: Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma. in FEBS letters 2008 (PubMed)

More Antibodies against Optineurin Interaction Partners

Human Optineurin (OPTN) interaction partners

  1. Nine OPTN variants were identified in Chinese sporadic ALS patients, including 5 known SNPs and four novel missense mutations: c.407C > T (p.A136V), c.1184A > G (p.K395R), c.1352T > C (p.I451T), and c.1546G > C (p.E516Q) (all heterozygous).

  2. OPTN 691_692insAG is a founder mutation in Moroccan and Ashkenazi Jews with ALS.

  3. A polymorphism of optineurin, M98K, associated with glaucoma, causes enhanced autophagy leading to transferrin receptor degradation and apoptotic death of retinal cells.

  4. Optineurin can also mediate the removal of protein aggregates through an ubiquitin-independent mechanism. This protein in addition can induce autophagy upon overexpression or mutation.

  5. Optineurin binding to myosin VI was al (show MYO6 Antibodies)so decreased in tissue lysates from sporadic amyotrophic lateral sclerosis spinal cords.

  6. Optineurin mediates its functions by interacting with various proteins and disease-causing mutations alter these interactions leading to functional defects in membrane vesicle trafficking, autophagy, signaling.

  7. Data suggest OPTN is involved in upregulation of innate immunity in mitosis; mechanism involves phosphorylation/mitochondrial translocation of TBK1 (NF-kB-activating kinase (show TBK1 Antibodies)) and phosphorylation/nuclear translocation of CYLD (show CYLD Antibodies) (cylindromatosis protein).

  8. Loss-of-function variants in OPTN and TBK1 (show TBK1 Antibodies) are associated with clinical and pathological frontotemporal dementia without motor neuron disease; TBK1 (show TBK1 Antibodies) mutations are common cause of frontotemporal lobar degeneration with TAR DNA-binding protein 43 (show TARDBP Antibodies) inclusions

  9. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies

  10. optineurin is recruited to ubiquitinated mitochondria downstream of PARK2 (show PARK2 Antibodies), and induces autophagosome assembly around mitochondria

Mouse (Murine) Optineurin (OPTN) interaction partners

  1. OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance.

  2. Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB (show NFKB1 Antibodies) and IFN-beta (show IFNB1 Antibodies) signaling.

  3. Mutation in Optineurin gene is associated with Glaucoma.

  4. Disruption in optineurin and myosin VI (show MYO6 Antibodies)-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  5. OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion.

  6. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies

  7. results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K

  8. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

  9. HACE1 (show HACE1 Antibodies)-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  10. Mutants in which the entire Ub-binding C-terminal region is deleted showed that optineurin is dispensable for NF-kappaB (show NFKB1 Antibodies) activation but necessary for optimal IRF3 (show IRF3 Antibodies) activation in immune cells.

Zebrafish Optineurin (OPTN) interaction partners

  1. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

Rhesus Monkey Optineurin (OPTN) interaction partners

  1. The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins.

Optineurin (OPTN) Antigen Profile

Protein Summary

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with anti-Optineurin (OPTN) Antibodies

  • optineurin (OPTN) antibody
  • optineurin (optn) antibody
  • optineurin (LOC100219034) antibody
  • optineurin (Optn) antibody
  • 4930441O07Rik antibody
  • ALS12 antibody
  • Fip2 antibody
  • fj52f04 antibody
  • GLC1E antibody
  • HIP7 antibody
  • HYPL antibody
  • NRP antibody
  • si:ch211-240l19.3 antibody
  • TFIIIA-INTP antibody
  • wu:fj52f04 antibody
  • zgc:66386 antibody
  • zgc:77868 antibody

Protein level used designations for anti-Optineurin (OPTN) Antibodies

optineurin , optineurin-like , E3-14.7K-interacting protein , FIP-2 , HIP-7 , Huntingtin interacting protein L , huntingtin yeast partner L , huntingtin-interacting protein 7 , huntingtin-interacting protein L , nemo-related protein , optic neuropathy-inducing protein , transcription factor IIIA-interacting protein , transcrption factor IIIA-interacting protein , tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains , 14.7K-interacting protein 2 , FIP-2-like protein , TFIIIA-INTP , ag9-C5

GENE ID SPECIES
736417 Pan troglodytes
100144665 Xenopus (Silurana) tropicalis
100195260 Salmo salar
100219034 Taeniopygia guttata
100398129 Callithrix jacchus
100597487 Nomascus leucogenys
10133 Homo sapiens
246294 Rattus norvegicus
478003 Canis lupus familiaris
397011 Sus scrofa
534150 Bos taurus
71648 Mus musculus
336159 Danio rerio
496250 Xenopus laevis
374079 Gallus gallus
100172952 Pongo abelii
574252 Macaca mulatta
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