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Optineurin Proteins (OPTN)

OPTN encodes the coiled-coil containing protein optineurin. Additionally we are shipping Optineurin Antibodies (90) and Optineurin Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OPTN 10133 Q96CV9
OPTN 246294 Q8R5M4
OPTN 71648 Q8K3K8
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Top Optineurin Proteins at

Showing 7 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
HOST_Baculovirus infected Insect Cells Human His tag,GST tag 100 μg Log in to see 16 Days
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Mouse His tag   100 μg Log in to see 11 to 13 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

OPTN Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Rat (Rattus)

Mouse (Murine)

More Proteins for Optineurin (OPTN) Interaction Partners

Human Optineurin (OPTN) interaction partners

  1. ALS (show IGFALS Proteins)-linked mutations in OPTN and TBK1 (show TBK1 Proteins) can interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegenerative disease.

  2. We conclude that OPTN mutations are associated with Amyotrophic lateral sclerosis

  3. In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN/TBK1 (show TBK1 Proteins) on ubiquitinated, damaged mitochondria

  4. Familial linkage studies for primary angle-closure glaucoma have been performed and identified OPTN causative primary angle-closure glaucoma disease

  5. Nine OPTN variants were identified in Chinese sporadic ALS patients, including 5 known SNPs and four novel missense mutations: c.407C > T (p.A136V), c.1184A > G (p.K395R), c.1352T > C (p.I451T), and c.1546G > C (p.E516Q) (all heterozygous).

  6. OPTN 691_692insAG is a founder mutation in Moroccan and Ashkenazi Jews with ALS.

  7. A polymorphism of optineurin, M98K, associated with glaucoma, causes enhanced autophagy leading to transferrin receptor degradation and apoptotic death of retinal cells.

  8. Optineurin can also mediate the removal of protein aggregates through an ubiquitin-independent mechanism. This protein in addition can induce autophagy upon overexpression or mutation.

  9. Optineurin binding to myosin VI was al (show MYO6 Proteins)so decreased in tissue lysates from sporadic amyotrophic lateral sclerosis spinal cords.

  10. Optineurin mediates its functions by interacting with various proteins and disease-causing mutations alter these interactions leading to functional defects in membrane vesicle trafficking, autophagy, signaling.

Mouse (Murine) Optineurin (OPTN) interaction partners

  1. OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance.

  2. Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB (show NFKB1 Proteins) and IFN-beta (show IFNB1 Proteins) signaling.

  3. Mutation in Optineurin gene is associated with Glaucoma.

  4. Disruption in optineurin and myosin VI (show MYO6 Proteins)-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  5. OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion.

  6. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies

  7. results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K

  8. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

  9. HACE1 (show HACE1 Proteins)-OPTN axis synergistically suppresses growth and tumorigenicity of lung cancer cells.

  10. Mutants in which the entire Ub-binding C-terminal region is deleted showed that optineurin is dispensable for NF-kappaB (show NFKB1 Proteins) activation but necessary for optimal IRF3 (show IRF3 Proteins) activation in immune cells.

Zebrafish Optineurin (OPTN) interaction partners

  1. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

Rhesus Monkey Optineurin (OPTN) interaction partners

  1. The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins.

Optineurin (OPTN) Protein Profile

Protein Summary

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene names and symbols associated with Optineurin Proteins (OPTN)

  • optineurin (OPTN)
  • optineurin (optn)
  • optineurin (LOC100219034)
  • optineurin (Optn)
  • 4930441O07Rik protein
  • ALS12 protein
  • Fip2 protein
  • fj52f04 protein
  • GLC1E protein
  • HIP7 protein
  • HYPL protein
  • NRP protein
  • si:ch211-240l19.3 protein
  • TFIIIA-INTP protein
  • wu:fj52f04 protein
  • zgc:66386 protein
  • zgc:77868 protein

Protein level used designations for Optineurin Proteins (OPTN)

optineurin , optineurin-like , E3-14.7K-interacting protein , FIP-2 , HIP-7 , Huntingtin interacting protein L , huntingtin yeast partner L , huntingtin-interacting protein 7 , huntingtin-interacting protein L , nemo-related protein , optic neuropathy-inducing protein , transcription factor IIIA-interacting protein , transcrption factor IIIA-interacting protein , tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains , 14.7K-interacting protein 2 , FIP-2-like protein , TFIIIA-INTP , ag9-C5

736417 Pan troglodytes
100144665 Xenopus (Silurana) tropicalis
100195260 Salmo salar
100219034 Taeniopygia guttata
100398129 Callithrix jacchus
100597487 Nomascus leucogenys
10133 Homo sapiens
246294 Rattus norvegicus
478003 Canis lupus familiaris
397011 Sus scrofa
534150 Bos taurus
71648 Mus musculus
336159 Danio rerio
496250 Xenopus laevis
374079 Gallus gallus
100172952 Pongo abelii
574252 Macaca mulatta
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