anti-Organic Anion Transporter 3 (OAT3) Antibodies

OAT3 encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic.

list all antibodies Gene Name GeneID UniProt
Anti-Human OAT3 OAT3 9376 Q8TCC7
Anti-Mouse OAT3 OAT3 19879 O88909
Anti-Rat OAT3 OAT3 83500 Q9R1U7
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More Antibodies against Organic Anion Transporter 3 Interaction Partners

Human Organic Anion Transporter 3 (OAT3) interaction partners

  1. SLC22A8 (show SLC22A8 Antibodies) variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.

  2. Uremic toxins, p-cresyl sulfate and indoxyl sulfate, are transported into endothelial cells by OAT1 (show KCNK3 Antibodies)/OAT3 (show SLC22A8 Antibodies).

  3. The putative promoter sequences from hOAT1 (SLC22A6 (show SLC22A6 Antibodies)) and hOAT3 (show SLC22A8 Antibodies) (SCL22A8) were cloned into a reporter plasmid.

  4. PPIs inhibit [(3)H]MTX (show MTX1 Antibodies) transport via hOAT3 (show SLC22A8 Antibodies) inhibition.

  5. The high efficacy of bendamustine in treating chronic lymphocytic leukemia might be partly due to the expression of OAT3 (show SLC22A8 Antibodies) in lymphoma cells and the high affinity of bendamustine for this transporter.

  6. Pemetrexed is a superior substrate to methotrexate for hOAT3 (show SLC22A8 Antibodies).

  7. In HEK293-Flp (show HPD Antibodies)-In cells, the OAT3 (show SLC22A8 Antibodies)-Ile305Phe variant had a lower maximum cefotaxime transport activity, Vmax , [159 +/- 3 nmol*(mg protein)(-1) /min (mean +/- SD)] compared with the reference OAT3 (show SLC22A8 Antibodies) [305 +/- 28 nmol*(mg protein)(-1) /min, (mean +/- SD), p < 0.01].

  8. The results confirmed that OAT1 (show KCNK3 Antibodies), OAT3 (show SLC22A8 Antibodies), OCT2, MATE1 (show SLC47A1 Antibodies), and MATE2-K (show SLC47A2 Antibodies) were coexpressed in tubular epithelial cells.

  9. transport of xanthurenic acid by OAT1 (show KCNK3 Antibodies) and OAT3 (show SLC22A8 Antibodies)

  10. Both hOAT1 (show SLC22A6 Antibodies) and hOAT3 (show SLC22A8 Antibodies) markedly stimulated the uptake of kynurenic acid into oocytes.

Mouse (Murine) Organic Anion Transporter 3 (OAT3) interaction partners

  1. OAT1 (show SLC22A6 Antibodies) plays a greater role in kidney proximal tubule metabolism and OAT3 (show SLC22A8 Antibodies) appears relatively more important in systemic metabolism, modulating levels of metabolites flowing through intestine, liver, and kidney

  2. Arsenic and mercury containing traditional Chinese medicine (Realgar and Cinnabar) probably induce kidney damage through inhibiting several members of the organic anion transporters (such as OAT1 (show SLC22A6 Antibodies) and OAT3 (show SLC22A8 Antibodies)).

  3. Specifically blocking its transport through OAT3 (show SLC22A8 Antibodies) or antioxidant treatment could prevent CMPF-induced beta cell dysfunction.

  4. Oat3 (show SLC22A8 Antibodies) also plays a role in bioenergetic pathways.

  5. At the protein level, mOat3 (show SLC22A8 Antibodies) and mOat1 (show SLC22A6 Antibodies) exhibit sex-dependent expression with an opposite pattern; mOat3 (show SLC22A8 Antibodies) is female dominant due to androgen inhibition, while mOat1 (show SLC22A6 Antibodies) is male dominant due to androgen stimulation.

  6. The results are consistent with a contribution of OAT3 (show SLC22A8 Antibodies) and possibly OAT1 (show SLC22A6 Antibodies) to renal creatinine secretion in mice.

  7. DAT (show SLC6A3 Antibodies) and Oct3 (show POU5F1 Antibodies) modulate nigrostriatal damage induced by PQ(2+)/PQ(+) redox cycling

  8. functional differences in the relative importance of OAT1 (show SLC22A6 Antibodies) and OAT3 (show SLC22A8 Antibodies) in antiviral handling in developing and mature tissue

  9. the ontogenic pattern of expression of OAT1 (show SLC22A6 Antibodies) and OAT3 (show SLC22A8 Antibodies) in the differentiating proximal tubules suggests that both transporters may function in the S2 segment in the fetus

  10. Oat3 (show SLC22A8 Antibodies) plays a key role in systemic detoxification and in control of the organic anion distribution in cerebrospinal fluid (Oat3 (show SLC22A8 Antibodies) = SLC22A8 (show SLC22A8 Antibodies) transporter)

Organic Anion Transporter 3 (OAT3) Antigen Profile

Protein Summary

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with OAT3

  • solute carrier family 22 (organic anion transporter), member 8 (SLC22A8) antibody
  • solute carrier family 22 (organic anion transporter), member 8 (Slc22a8) antibody
  • Oat3 antibody
  • OCT3 antibody
  • Roct antibody

Protein level used designations for OAT3

hOAT3 , organic anion transporter 3 , solute carrier family 22 member 8 , reduced in osteosclerosis transporter , solute carrier family 22, member 8 , rOat3 , solute carrier family 22 ,member 8 , rbOAT3 , renal organic anion transporter 3

9376 Homo sapiens
19879 Mus musculus
83500 Rattus norvegicus
404128 Bos taurus
100008845 Oryctolagus cuniculus
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