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Organic Cation Transporter 3 Proteins (OCT3)

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Organic Cation Transporter 3 Antibodies (37) and Organic Cation Transporter 3 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OCT3 OCT3 29504 O88446
OCT3 6581 O75751
OCT3 20519 Q9WTW5
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Top Organic Cation Transporter 3 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

OCT3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Organic Cation Transporter 3 (OCT3) Interaction Partners

Human Organic Cation Transporter 3 (OCT3) interaction partners

  1. Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Proteins)-3) in drug transportation.

  2. Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  3. The markers of EMT (show ITK Proteins) were detected by using Western blot.

  4. Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (show CHDH Proteins)).

  5. Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3 (show POU5F1 Proteins).

  6. There was no association between rs7758229 in 6q26-q27/SLC22A3 and the risk of colorectal cancer in a Chinese population.

  7. Decreasing expression of OCT3 and MATE1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation.

  8. Our studies demonstrate that genetic polymorphisms in the proximal promoter region of OCT3 (show POU5F1 Proteins) alter the transcription rate of the gene and may be associated with altered expression levels of OCT3 (show POU5F1 Proteins) in human liver.

  9. The increased Wnt3 (show WNT3 Proteins) in the trastuzumab-resistant cells also promoted a partial EMT (show ITK Proteins)-like transition.

  10. PDLIM5 (show PDLIM5 Proteins) (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (show NKX3-1 Proteins) (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men.

Mouse (Murine) Organic Cation Transporter 3 (OCT3) interaction partners

  1. Study showed that few, if any, 5-HT (show DDC Proteins) neurons in the dorsal raphe are resistant to loss of Pet-1 (show FEV Proteins) for expression of Slc22a3

  2. Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.

  3. These results demonstrate that OCT3 (show POU5F1 Proteins) is responsible for metformin accumulation and secretion in salivary glands.

  4. Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Proteins), Slc22a2 (show SLC22A2 Proteins) and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.

  5. Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.

  6. evidence for a new means of downregulating IL-4 (show IL4 Proteins) production by basophils, both in vitro and in vivo, through OCT3 (show POU5F1 Proteins) targeted by 5-HT (show DDC Proteins) and pharmacologic ligands.

  7. these results show that reduced 5-HT (show DDC Proteins) clearance following HPA (show HPSE Proteins) axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3 (show POU5F1 Proteins)

  8. Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.

  9. In 5HT transporter (show SLC6A4 Proteins)-deficient mice, OCT3 (show POU5F1 Proteins) mRNA concentrations were significantly increased in the hippocampus, but not in other brain regions

  10. Imprinted silencing of Slc22a3 does not need transcriptional overlap between Igf2r (show IGF2R Proteins) and Air.

Organic Cation Transporter 3 (OCT3) Protein Profile

Protein Summary

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.

Gene names and symbols associated with OCT3

  • organic cation transporter 3 (LOC100008931)
  • solute carrier family 22 (extraneuronal monoamine transporter), member 3 (SLC22A3)
  • solute carrier family 22 (organic cation transporter), member 3 (Slc22a3)
  • solute carrier family 22 (organic cation transporter), member 3 (SLC22A3)
  • EMT protein
  • EMTH protein
  • Oct3 protein
  • Orct3 protein
  • Slca22a3 protein

Protein level used designations for OCT3

organic cation transporter 3 , extraneuronal monoamine extraneuronal monoamine , solute carrier family 22 member 3 , solute carrier family 22 (extraneuronal monoamine transporter), member 3 , solute carrier family 22, member 3 , EMT organic cation transporter 3 , extraneuronal monoamine transporter

GENE ID SPECIES
100008931 Oryctolagus cuniculus
476261 Canis lupus familiaris
100142677 Sus scrofa
29504 Rattus norvegicus
6581 Homo sapiens
20519 Mus musculus
535665 Bos taurus
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