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Organic Solute Transporter alpha Proteins (OSTALPHA)

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Additionally we are shipping Organic Solute Transporter alpha Antibodies (21) and Organic Solute Transporter alpha Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OSTALPHA OSTALPHA 303879  
OSTALPHA 200931 Q86UW1
OSTALPHA 106407 Q8R000
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Top Organic Solute Transporter alpha Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

OSTALPHA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Organic Solute Transporter alpha (OSTALPHA) Interaction Partners

Human Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. Hepatic OSTalpha-OSTbeta (show OSTBETA Proteins) expression is induced by hypoxia.

  2. Ostbeta (show OSTBETA Proteins) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (show OSTBETA Proteins) critical for these processes.

  3. The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (show OSTBETA Proteins) in different tissues.

  4. OSTalpha has roles in biological transport and is widely expressed in human tissues

  5. overexpression of hu (show OSTBETA Proteins)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (show NR1H4 Proteins) and the activation of FXR target genes

  6. OSTalpha/OSTbeta (show OSTBETA Proteins) expression is induced by bile acids through ligand-dependent transactivation of both OST (show DDOST Proteins) genes by the nuclear bile acid receptor (show NR1H4 Proteins)/farnesoid X receptor (show xpr1 Proteins) (FXR (show NR1H4 Proteins)).

  7. the selective localization of OSTalpha and OSTbeta (show OSTBETA Proteins) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

  8. These results indicate that expression of Ostalpha and Ostbeta (show OSTBETA Proteins) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (show NR1H4 Proteins).

  9. Demonstrate association of OST-alpha and OST-beta (show OSTBETA Proteins) to determine trafficking to plasma membrane and activity.

  10. The mRNA expression of OSTalpha-OSTbeta (show OSTBETA Proteins) was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta (show OSTBETA Proteins): 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers

Mouse (Murine) Organic Solute Transporter alpha (OSTALPHA) interaction partners

  1. These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (show INS Proteins) resistance.

  2. Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (show APOE Proteins)(-/-) mice deficient in Ostalpha.

  3. Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression

  4. Inactivation of FXR (show NR1H4 Proteins) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.

  5. Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.

  6. OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (show SULT2A1 Proteins) homeostasis

  7. These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.

  8. Co-expression of mouse Ostalpha-Ostbeta (show OSTBETA Proteins), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate

  9. OSTalpha and OSTbeta (show OSTBETA Proteins) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (show NR1H4 Proteins)-/-, mice

  10. the selective localization of OSTalpha and OSTbeta (show OSTBETA Proteins) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.

Organic Solute Transporter alpha (OSTALPHA) Protein Profile

Protein Summary

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).

Gene names and symbols associated with OSTALPHA

  • solute carrier family 51, alpha subunit (Slc51a)
  • solute carrier family 51, alpha subunit (SLC51A)
  • AV001382 protein
  • AW261577 protein
  • D630035O19Rik protein
  • OSTA protein
  • OSTALPHA protein
  • RGD1311100 protein

Protein level used designations for OSTALPHA

organic solute transporter alpha , organic solute transporter subunit alpha , OST-alpha , organic solute transporter, alpha subunit , solute carrier family 51 subunit alpha

GENE ID SPECIES
303879 Rattus norvegicus
200931 Homo sapiens
106407 Mus musculus
516626 Bos taurus
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