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Origin Recognition Complex, Subunit 6 Proteins (ORC6)

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Additionally we are shipping ORC6 Antibodies (52) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat ORC6 ORC6 291927  
ORC6 23594 Q9Y5N6
ORC6 56452  
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Top ORC6 Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,647.33
Details
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 56 to 66 Days
$2,684.00
Details
Yeast Yeast His tag   1 mg Log in to see 56 to 66 Days
$3,215.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

ORC6 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Origin Recognition Complex, Subunit 6 (ORC6) Interaction Partners

Fruit Fly (Drosophila melanogaster) Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

  1. In order to study the effects of Meier-Gorlin syndrome (MGS (show GYS1 Proteins)) mutation in an animal model system, MGS (show GYS1 Proteins) mutation in Orc6 was introduced and established Drosophila model of MGS (show GYS1 Proteins).

  2. Drosophila Orc6 protein, the smallest subunit of the origin recognition complex (ORC), directly binds to septin complex and facilitates septin filament formation.

  3. Drosophila ORC6 protein cytokinetic function resides in a domain distinct from its replication activity

  4. These studies provide a molecular analysis for the functional requirement of Orc6 in replicative functions of ORC in Drosophila and suggest that Orc6 may contribute to the sequence preferences of ORC in targeting to the origins.

  5. These results show that the interaction of Orc6 with the septin (show SEPT1 Proteins) complex is dependent on the coiled-coil domain of Pnut, and suggest an active role for Orc6 in septin (show SEPT1 Proteins) complex function.

  6. In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans.

Human Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

  1. The present report expands the clinical phenotype associated with ORC6 mutations to include severely abnormal embryological development suggesting a possible genotype-phenotype correlation.

  2. our results suggest that Meier-Gorlin syndrome mutations in Orc6 impair the formation of ORC hexamers, interfering with appropriate ORC functions

  3. findings show that Orc6 not only interacts with Orc1 (show ORC1L Proteins)-Orc5 (show ORC5 Proteins) but also with the initiation factor Cdc6 (show CDC6 Proteins), and that Orc6 functions at different stages of the replication initiation process.

  4. Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB (show GTF2B Proteins).

  5. results implicate Orc6 as an essential gene that coordinates chromosome replication and segregation with cytokinesis

  6. Study using HCT116 haplo-insufficient (show TGFb Proteins) cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3 (show ORC3 Proteins), -4, and -6 subunit binding.

  7. Orc6 has a role in sensitizing human colon cancer cells to 5-fluorouracil and cisplatin

  8. In a cross-species complementation experiment, the expression of human Orc6 in Drosophila Orc6 mutant cells rescued DNA replication, suggesting that this function of the protein is conserved among metazoans.

Mouse (Murine) Origin Recognition Complex, Subunit 6 (ORC6) interaction partners

  1. Study reports that ORC6L is another component required for acquisition of DNA replication competence that is absent in mouse oocytes.

ORC6 Protein Profile

Protein Summary

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis.

Gene names and symbols associated with ORC6

  • origin recognition complex, subunit 6 (Orc6)
  • Origin recognition complex subunit 6 (Orc6)
  • origin recognition complex, subunit 6 (ORC6)
  • origin recognition complex subunit 6 (ORC6)
  • origin recognition complex subunit 6 (CpipJ_CPIJ005016)
  • origin recognition complex subunit 6 (SJAG_01267)
  • origin recognition complex subunit 6 (orcF)
  • origin recognition complex subunit 6 (LOC100284755)
  • origin recognition complex, subunit 6 (orc6)
  • 6720420I10Rik protein
  • ARABIDOPSIS THALIANA ORIGIN RECOGNITION COMPLEX PROTEIN 6 protein
  • ATORC6 protein
  • CG1584 protein
  • DDBDRAFT_0186183 protein
  • DDBDRAFT_0233113 protein
  • DDB_0186183 protein
  • DDB_0233113 protein
  • Dmel\\CG1584 protein
  • DmORC6 protein
  • DmORC 6 protein
  • LOC100284755 protein
  • ORC protein
  • orc6 protein
  • orc6l protein
  • origin recognition complex protein 6 protein
  • ORIGIN RECOGNITION COMPLEX SUBUNIT 6 protein
  • rDmORC protein
  • T2P11.3 protein
  • T2P11_3 protein

Protein level used designations for ORC6

origin recognition complex subunit 6 , origin recognition complex, subunit 6-like , CG1584-PA , Orc6-PA , origin recognition complex, subunit 6 like

GENE ID SPECIES
291927 Rattus norvegicus
36017 Drosophila melanogaster
415749 Gallus gallus
465140 Pan troglodytes
839227 Arabidopsis thaliana
6036630 Culex quinquefasciatus
7048414 Schizosaccharomyces japonicus yFS275
8624765 Dictyostelium discoideum AX4
100284755 Zea mays
549939 Xenopus (Silurana) tropicalis
23594 Homo sapiens
482492 Canis lupus familiaris
515476 Bos taurus
56452 Mus musculus
Selected quality suppliers for ORC6 Proteins (ORC6)
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