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Orthodenticle Homeobox 2 Proteins (OTX2)

OTX2 encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. Additionally we are shipping Orthodenticle Homeobox 2 Antibodies (81) and Orthodenticle Homeobox 2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OTX2 5015 P32243
Rat OTX2 OTX2 305858  
OTX2 18424  
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Top Orthodenticle Homeobox 2 Proteins at

Showing 6 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
Yeast Xenopus tropicalis His tag   1 mg Log in to see 56 to 66 Days
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 5 Days

OTX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

More Proteins for Orthodenticle Homeobox 2 (OTX2) Interaction Partners

Human Orthodenticle Homeobox 2 (OTX2) interaction partners

  1. demonstrated the role of OTX2 on TAp63 regulation necessary for the correct formation of macular neuroepithelium

  2. Loss of OTX2 expression resulted in decreased expression of C-MYC (show MYC Proteins) and CRX (show CRX Proteins), genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation

  3. A novel role for OTX2 in self-renewal and migration of human embryonic neural precursors and Medulloblastoma cells, is reported.

  4. We showed that miR (show MLXIP Proteins)-410 directly regulates predicted target genes OTX2 and RPE65 (show RPE65 Proteins).

  5. This epigenome-wide DNA methylation (show HELLS Proteins) analysis in postmortem hippocampus and prefrontal cortex specimens confirmed OTX2 DNA methylation (show HELLS Proteins) profiles in major depression

  6. OTX2 overexpression is associated with medulloblastoma.

  7. SOX2 (show SOX2 Proteins), OTX2 and PAX6 (show PAX6 Proteins) analysis in subjects with anophthalmia and microphthalmia

  8. Agnathia-otocephaly complex and asymmetric velopharyngeal insufficiency due to an in-frame duplication in OTX2.

  9. OTX2 mutations cause autosomal dominant pattern dystrophy of the retinal pigment epithelium.

  10. Endogenous OTX2 from a medulloblastoma cell line is O-GlcNAcylated at several sites.

Xenopus laevis Orthodenticle Homeobox 2 (OTX2) interaction partners

  1. barH-like homeobox-2 (show BARHL2 Proteins) gene barhl2 (show BARHL2 Proteins) acts downstream of orthodentricle-2 and together with iroquois-3 in establishment of the caudal forebrain signaling center induced by Sonic Hedgehog (show SHH Proteins)

  2. While otx2 and otx5 are both capable to promote cement gland formation, otx1 is not.

  3. direct interaction and interdependence between the Otx2 and Sox2 (show SOX2 Proteins) proteins coordinate Rax (show RAX Proteins) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.

Zebrafish Orthodenticle Homeobox 2 (OTX2) interaction partners

  1. Lbh (show LBH Proteins)-like is a new regulator of photoreceptor differentiation directly through modulating otx2 expression in zebrafish.

  2. These findings suggest that one or more Otx targets in addition to mitfa (show MITF Proteins) and mitfb (show MITF Proteins), possibly another mitf (show MITF Proteins) family member, are necessary for development of the retinal pigmented epithelium in zebrafish.

  3. In vertebrates, the Otx2 promoter acquires multiple, spatiotemporally specific cis (show CISH Proteins)-regulators in order to precisely control highly coordinated processes in head development.

  4. The Zona limitans intrathalamica is induced within the competence area established by Otx1l/2, and is posteriorly restricted by Irx1b.

Mouse (Murine) Orthodenticle Homeobox 2 (OTX2) interaction partners

  1. the Otx2 interactome in the adult neural retina

  2. Otx2S is a novel variant of the Otx2 gene with a deletion within the homeodomain sequence. Otx2S is expressed in both the neural retina and retinal pigmented epithelium, and encodes a protein that is targeted to the nucleus.

  3. Otx2 critically depends on Lmx1b (show LMX1B Proteins) for the formation of mdDA neurons.

  4. Otx2 was required for ventral, but not dorsal, identity, thus controlling the production of specific MGE derivatives.

  5. Deregulated FGF8 (show FGF8 Proteins) and Otx2/Gbx2 (show GBX2 Proteins) gene expression underlies cerebellar vermis hypoplasia in mouse model of CHARGE syndrome.

  6. Otx2 is required for thyroid hormone (show PTH Proteins)-dependent DA neuron differentiation from embryonic VM NSCs.

  7. Otx2 acts downstream of N-myc (show MYCN Proteins) and is essential for patterning and spatial restriction of the sensory domain of the mammalian cochlea.

  8. Otx2 expression early in head development is important for establishing normal craniofacial features including development of the brain, eyes and pituitary gland.

  9. OTX2 and DKK1 (show DKK1 Proteins) exhibit asymmetric expression in the anterior ventral endoderm during embryonic anterior-posterior axis formation.

  10. After cell-cycle exit, Sox6 selectively localizes to substantia nigra pars (show EPRS Proteins) compacta neurons, while Otx2 and Nolz1 (show ZNF503 Proteins) are expressed in a subset of ventral tegmental area neurons.

Orthodenticle Homeobox 2 (OTX2) Protein Profile

Protein Summary

This gene encodes a member of the bicoid subfamily of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain, craniofacial, and sensory organ development. The encoded protein also influences the proliferation and differentiation of dopaminergic neuronal progenitor cells during mitosis. Mutations in this gene cause syndromic microphthalmia 5 (MCOPS5) and combined pituitary hormone deficiency 6 (CPHD6). This gene is also suspected of having an oncogenic role in medulloblastoma. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Pseudogenes of this gene are known to exist on chromosomes two and nine.

Gene names and symbols associated with OTX2

  • orthodenticle homeobox 2 (OTX2)
  • orthodenticle homeobox 2 (Otx2)
  • orthodenticle homeobox 2 (otx2-a)
  • orthodenticle homolog 2 (otx2)
  • orthodenticle homolog 2 (Drosophila) (Otx2)
  • CPHD6 protein
  • E130306E05Rik protein
  • id:ibd2915 protein
  • MCOPS5 protein
  • otx-2 protein
  • otx2 protein
  • Xotx-2 protein
  • Xotx2 protein
  • zgc:136535 protein
  • zotx-2 protein
  • zOtx2 protein

Protein level used designations for OTX2

homeobox protein OTX2 , orthodenticle homolog 2 , orthodenticle homeobox protein 2 , homeobox Otx2 , homeobox protein OTX2-A , orthodenticle 2-A , orthodenticle-A-like protein A , xOTX2-A , etID309955.17

5015 Homo sapiens
395191 Gallus gallus
490708 Canis lupus familiaris
538953 Bos taurus
100009374 Oryctolagus cuniculus
305858 Rattus norvegicus
399342 Xenopus laevis
30501 Danio rerio
18424 Mus musculus
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