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Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. Additionally we are shipping OSCAR Antibodies (70) and OSCAR Kits (27) and many more products for this protein.
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Data suggest that OSCAR is a collagen receptor (show ITGA2 Proteins) that binds to specific collagen motifs and costimulates osteoclastogenesis in DAP12 (show TYROBP Proteins)-deficient humans and mice.
PU.1 and MITF (show MITF Proteins) transcription factors synergistically activate OSCAR gene expression, which is further enhanced by the TRANCE-induced MKK6 (show MAP2K6 Proteins)/p38 (show CRK Proteins) signaling cascade.
the FcRgamma (show FCER1G Proteins)-mediated signal transduction by OSCAR is involved in osteoclast differentiation
OSCAR but not TREM-2 (show TREM2 Proteins) is involved in the positive feedback loop of the immunoreceptor-NFATc1 (show NFATC1 Proteins) pathway during osteoclastogenesis
analysis of a positive feedback circuit of TRANCE-induced activation of NFATc1 (show NFATC1 Proteins), involving NFATc1 (show NFATC1 Proteins)-mediated OSCAR expression and its subsequent activation of NFATc1 (show NFATC1 Proteins), necessary for efficient differentiation of osteoclasts
The overexpression of PIAS3 (show PIAS3 Proteins) attenuates osteoclast formation and down-regulates the expression of NFATc1 (show NFATC1 Proteins) and osteoclast-associated receptor (OSCAR), which are important modulators in osteoclastogenesis.
Results indicate that USFs 1 and 2 serve as modulators in the induction of OSCAR and RANKL (show TNFSF11 Proteins)-mediated osteoclastogenesis.
Each domain of OSCAR binds a collagen triple-helical peptide; the primary site is on the C-terminal domain in contrast to GPVI (show GP6 Proteins) and LAIR-1 (show LAIR1 Proteins).
OSCAR is a receptor for surfactant protein D that activates TNF-alpha release from human CCR2+ inflammatory monocytes.
Data indicate that osteoclast associated receptor (OSCAR) was strongly expressed by the vasculature of active rheumatoid arthritis (RA) patients.
endothelial cell-derived OSCAR was found to be involved in the STAT (show STAT1 Proteins) signaling pathway and to affect monocyte adhesion.
OSCAR is expressed in vascular endothelial cells and is regulated by oxLDL involving NFATc1 (show NFATC1 Proteins)
hOSCAR thus represents a novel class of molecule expressed by dendritic cells involved in the initiation of the immune response.
ligation of OSCAR promotes dendritic cell survival by an ERK (show EPHB2 Proteins)- and PI3K (show PIK3CA Proteins)-dependent pathway, linked to expression of the Bcl-2 (show BCL2 Proteins) and Bcl-x(L (show BCL2L1 Proteins)) antiapoptotic molecules
Human OSCAR mediates the rescue from apoptosis and the cooperation between dendritic cells and antigen-specific T cells that is prevented by CD85j (show LILRB1 Proteins) receptor.
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
osteoclast associated, immunoglobulin-like receptor
, osteoclast associated, immunoglobulin-like receptor, isoform 4
, osteoclast-associated immunoglobulin-like receptor
, osteoclast-associated receptor OSCAR
, osteoclast associated receptor OSCAR-S1
, osteoclast associated receptor OSCAR-S2
, poly-Ig receptor 3
, polymeric immunoglobulin receptor 3
, osteoclast associated receptor