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Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008].. Additionally we are shipping Osteoclast Stimulating Factor 1 Antibodies (82) and Osteoclast Stimulating Factor 1 Kits (23) and many more products for this protein.
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Data show that SH3P2 was phosphorylated on Ser (show SIGLEC1 Proteins)(202) by ribosomal S6 kinase (show RPS6KB1 Proteins) (RSK (show RPS6KA1 Proteins)) in an ERK (show EPHB2 Proteins) pathway-dependent manner, and such phosphorylation inhibited the ability of SH3P2 to suppress cell motility.
SH3P2, a novel component of adhesion sites, is involved in Cbl (show CBL Proteins) and Src (show SRC Proteins)-mediated pathways
The SH3 domain structure of osteoclast stimulating factor at atomic resolution provides an accurate framework for structure-based design of its inhibitors.
The peptide-binding groove of OSTF-SH3 domain adopts a conformation different from other SH3 domains and probably needs a conformational switch for binding to its proline-rich ligand; this status is possibly regulated by the C-terminal ankyrin repeats.
Ptn (show PTN Proteins) may play a vital role in the progesterone-induced decidualization pathway via C/EBPB (show CEBPB Proteins)-cyclic AMP (show TMPRSS5 Proteins)-Hand2 (show HAND2 Proteins) signaling.
The results of this study suggested that regulation of the PTN (show PTN Proteins) signaling pathways may constitute new therapeutic opportunities particularly in those neurological disorders characterized by increased PTN (show PTN Proteins) cerebral levels and neuroinflammation.
these data indicate that PTN (show PTN Proteins)-PTPRZ (show PTPRZ1 Proteins)-A signaling controls the timing of oligodendrocyte precursor cell differentiation in vivo, in which the CS moiety of PTPRZ (show PTPRZ1 Proteins) receptors maintains them in a monomeric active state until its ligand binding.
findings link pleiotrophin abundance in gliomas with survival in humans and mice, and show that pleiotrophin promotes glioma progression through increased VEGF deposition and vascular abnormalization.
antagonizes Brd2 (show BRD2 Proteins) promoting cell differentiation associated with the neural tube: spinal cord neurogenesis and neural crest migration
PTN-mediated hematopoietic regeneration occurs in a RAS-dependent manner.
the absence of PTN (show PTN Proteins) in vivo is associated with disruption of specific cognitive and affective processes
The results of this study indicated that PTN (show PTN Proteins) may be a novel genetic factor of importance in alcohol use disorders.
data suggest that the spinal antinociceptive effects caused by stimulation of alpha2-adrenoceptors are differentially regulated by endogenous expression of PTN (show PTN Proteins)
PTN (show PTN Proteins) overexpression exerts various effects on sarcolemma ion channel expression/function and resting cytosolic calcium concentrations in soleus and extensor digitorum longus muscles.
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998
osteoclast stimulating factor 1
, osteoclast-stimulating factor 1
, SH3 domain protein 3
, heparin affin regulatory peptide
, heparin-binding brain mitogen
, heparin-binding growth factor 8
, heparin-binding growth-associated molecule
, heparin-binding neurite promoting factor
, heparin-binding neurotorphic factor
, heparin-binding neutrophic factor
, osteoblast-specific factor 1
, osteoblastic cell factor