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Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Additionally we are shipping OCSTAMP Antibodies (4) and many more products for this protein.
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Restoring OC-STAMP in knockout cells by lentiviral transduction rescued fusion and resorption.
OC-STAMP is a regulatory molecule for FBGCs; and that they are functionally distinct from OCs, despite similarities in gene expression profile, podosome belt formation, and TRAP expression.
Fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.
The osteoclast differentiation needs the coordinated expression of OC-STAMP with several molecules required for transcription, signaling transduction, and cell fusion.
OC-STAMP is a previously unknown, RANKL (show TNFSF11 Proteins)-induced, multipass transmembrane protein that promotes the formation of multinucleated osteoclasts. (Osteoclast stimulatory transmembrane protein)
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity).
transmembrane protein C20orf123
, transmembrane protein C20orf123 homolog