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anti-Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Antibodies

OSTM1 encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. Additionally we are shipping OSTM1 Proteins (7) and OSTM1 Kits (2) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OSTM1 28962 Q86WC4
OSTM1 14628 Q8BGT0
OSTM1 499474  
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Top anti-OSTM1 Antibodies at antibodies-online.com

Showing 10 out of 43 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB OSTM1 Antibody (C-term)  western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the OSTM1  Antibody detected the OSTM1  protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated ELISA   100 μg Log in to see 16 Days
$218.90
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney labeled with Rabbit Anti OSTM1 Polyclonal Antibody, Unconjugated (ABIN1387308) at 1:200 followed by conjugation to the secondary antibody and DAB staining L1 human colon carcinoma lysates probed with Anti OSTM1 Polyclonal Antibody, Unconjugated (ABIN1387308) at 1:200 overnight at 4 °C. Followed by conjugation to secondary antibody at 1:3000 for 90 min at 37 °C. Predicted band 37kD. Observed band size:37kD. 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$163.90
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 16 Days
$273.90
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit FITC IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

OSTM1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-OSTM1 Antibodies

  1. Human Monoclonal OSTM1 Primary Antibody for ELISA - ABIN1997769 : Chalhoub, Benachenhou, Rajapurohitam, Pata, Ferron, Frattini, Villa, Vacher: Grey-lethal mutation induces severe malignant autosomal recessive osteopetrosis in mouse and human. in Nature medicine 2003 (PubMed)
    Show all 2 references for ABIN1997769

  2. Human Monoclonal OSTM1 Primary Antibody for ELISA - ABIN1997767 : Lange, Wartosch, Jentsch, Fuhrmann: ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function. in Nature 2006 (PubMed)
    Show all 2 references for ABIN1997767

More Antibodies against OSTM1 Interaction Partners

Human Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) interaction partners

  1. KIF5B (show KIF5B Antibodies) is essential for Ostm1 intracellular dispersion.

  2. Ostm1 has a primary and autonomous role in neuronal homeostasis

  3. Common gating underlies the slow voltage activation of ClC-7 (show CLCN7 Antibodies).

  4. we describe for the first time homozygous microdeletions of different sizes affecting the OSTM1 gene in two unrelated consanguineous families with children suffering from neuronopathic infantile malignant osteopetrosi

  5. The authors show that both the aminoterminus and transmembrane span of the Ostm1 beta-subunit (show POLG Antibodies) are required for ClC-7 (show CLCN7 Antibodies) Cl(-)/H(+)-exchange, whereas the Ostm1 transmembrane domain suffices for its ClC-7 (show CLCN7 Antibodies)-dependent trafficking to lysosomes.

  6. mutation in the human GL gene leads to severe recessive osteopetros (show CSF1 Antibodies)is

  7. The human GIPN gene has 6 exons and 5 introns, and encodes a 334-aa protein.

  8. A novel mutation affecting the OSTM1 locus responsible for ARO (show CYP19A1 Antibodies). In addition to common clinical features of osteopetrosis (show CSF1 Antibodies), the patient developed a unique neuronal pathology that provided evidence for the role of OSTM1 in normal neuronal cell development.

  9. This study reports on a 12-month-old female with recessive OSMT1 mutations and neuroimaging findings suggesting a malignant infantile osteopetrosis (show CSF1 Antibodies).

  10. mutations in OSTM1 such as the C-terminal deletion mutant studied herein provoke dysregulation of the canonical Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling pathway, providing a molecular basis for severe autosomal recessive osteopetrosis (show CSF1 Antibodies)

Mouse (Murine) Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) interaction partners

  1. KIF5B (show KIF5B Antibodies) is essential for Ostm1 intracellular dispersion.

  2. Truncated OSTM1 significantly inhibited the expression of osteoclast marker genes through the down-regulation of the BLIMP1 (show PRDM1 Antibodies)-NFATc1 (show NFATC1 Antibodies) axis.

  3. Our in vivo structure-function analysis of ClC-7 (show CLCN7 Antibodies) reveals that both protein-protein interactions and ion transport must be considered in the pathogenesis of ClC-7 (show CLCN7 Antibodies)-related diseases.

  4. Ostm1 has a primary and autonomous role in neuronal homeostasis

  5. Omi (show HTRA2 Antibodies) is a recessive mutation in the Ostm1 gene affecting teeth and coat color.

  6. Ostm1 is a bona fide target of miR (show MLXIP Antibodies)-140, which is significantly decreased during adipogenic differentiation.

  7. Neuropathologic changes similar to neuronal ceroid lipofuscinosis (show CLN6 Antibodies) are found in osteoporosis associated transmembrane protein 1 (show TMEM1 Antibodies) (Ostml)-deficient mice.

  8. mutation induces severe malignant autosomal recessive osteopetrosis (show CSF1 Antibodies); studies show that Gl protein function is absolutely required for osteoclast and melanocyte maturation and function

  9. both ClC-7 (show CLCN7 Antibodies) and Ostm1 proteins co-localize in late endosomes and lysosomes of various tissues, as well as in the ruffled border of bone-resorbing osteoclasts

  10. microphthalmia transcription factor (show MITF Antibodies) regulates Clcn7 and Ostm1 expression in osteoclasts

OSTM1 Antigen Profile

Protein Summary

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis.

Gene names and symbols associated with OSTM1

  • osteopetrosis associated transmembrane protein 1 (OSTM1) antibody
  • osteopetrosis associated transmembrane protein 1 (ostm1) antibody
  • osteopetrosis associated transmembrane protein 1 (Ostm1) antibody
  • osteopetrosis-associated transmembrane protein 1 (GL) antibody
  • 1200002H13Rik antibody
  • Gipn antibody
  • gl antibody
  • HSPC019 antibody
  • MGC145644 antibody
  • OPTB5 antibody
  • OSTM1 antibody
  • si:ch73-257c13.3 antibody

Protein level used designations for OSTM1

osteopetrosis-associated transmembrane protein 1 , osteopetrosis associated transmembrane protein 1 , GAIP-interacting protein N terminus , chloride channel 7 beta subunit , grey-lethal osteopetrosis , grey lethal osteopetrosis , GAIP interacting protein N terminus , osteopetrosis associated transmembrane protein 1-like

GENE ID SPECIES
421773 Gallus gallus
518522 Bos taurus
701341 Macaca mulatta
739203 Pan troglodytes
780037 Xenopus (Silurana) tropicalis
100137453 Papio anubis
100320445 Danio rerio
100328697 Oryctolagus cuniculus
28962 Homo sapiens
14628 Mus musculus
499474 Rattus norvegicus
100049681 Sus scrofa
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