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Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin Proteins (OS9)

OS9 encodes a protein that is highly expressed in osteosarcomas. Additionally we are shipping OS9 Antibodies (63) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
OS9 216440 Q8K2C7
Rat OS9 OS9 362891 Q5RKH6
OS9 10956 Q13438
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Top OS9 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

OS9 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) Interaction Partners

Zebrafish Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) interaction partners

  1. OS-9 regulates the secretory transport of TRPV4 (show TRPV4 Proteins) and appears to protect TRPV4 (show TRPV4 Proteins) subunits from the precocious ubiquitination and ER-associated degradation.

Mouse (Murine) Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) interaction partners

  1. Data suggest renal cell lines exhibit an OS9-mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 (solute carrier family 12 member 1 (show SLC12A1 Proteins)) prior to glycosylation/processing.

  2. The depletion of OS-9 in 3T3-L1 adipocytes impaired cell function in terms of triacylglycerol storage, and slightly influenced cell differentiation.

  3. OS-9 regulates the secretory transport of TRPV4 (show TRPV4 Proteins) and appears to protect TRPV4 (show TRPV4 Proteins) subunits from the precocious ubiquitination and ER-associated degradation.

Human Osteosarcoma Amplified 9, Endoplasmic Reticulum Lectin (OS9) interaction partners

  1. OS-9 up-regulates occludin (show OCLN Proteins) and claudin-1 (show CLDN7 Proteins) by activating the MAP kinase (MAPK (show MAPK1 Proteins)) pathway, and thus protects the epithelial barrier function of Caco-2 monolayer under hypoxia condition.

  2. EDEM2 (show EDEM2 Proteins) and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog (show SHH Proteins)

  3. Unique regions mediate the interaction between OS-9 and GRP94 (show HSP90B1 Proteins).

  4. It delivers mutant neuroserpin (show SERPINI1 Proteins) to ERAD by recognition of glycan side chains and provide the first in vivo proof of involvement of ERAD in degradation of mutant neuroserpin (show SERPINI1 Proteins).

  5. long non-coding RNA ENST00000480739 suppresses tumour cell invasion by regulating OS-9 and HIF-1alpha (show HIF1A Proteins) in pancreatic ductal adenocarcinoma.

  6. Data indicate that the interaction of OS-9 and XTP3-B with CD147(CG) was inhibited by mutations to conserved residues in their lectin domains.

  7. OS-9 plays no direct functional role in HIF degradation since physical interaction of OS-9 with oxygen sensing HIF prolyl hydroxylases cannot occur in vivo due to their different subcellular localization

  8. The OS-9 specifically recognizes Manalpha1,6Manalpha1,6Man residues on the processed C-arm through the continuous double tryptophan (WW) motif.

  9. The sugar-binding ability of human OS-9 and its involvement in ER-associated degradation

  10. Identification of a peptide, resulting from a point mutation in gene OS-9, recognized by cytolytic T lymphocytes on a human melanoma.

OS9 Protein Profile

Protein Summary

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with OS9

  • osteosarcoma amplified 9, endoplasmic reticulum lectin (OS9)
  • amplified in osteosarcoma (os9)
  • amplified in osteosarcoma (Os9)
  • osteosarcoma amplified 9 (Os9)
  • 4632413K17Rik protein
  • AU022351 protein
  • ERLEC2 protein
  • Os-9 protein
  • zgc:153838 protein

Protein level used designations for OS9

amplified in osteosarcoma , osteosarcoma amplified 9, endoplasmic reticulum associated protein , protein OS-9 , osteosarcoma amplified 9 , amplified in osteosarcoma 9 , endoplasmic reticulum lectin 2 , erlectin 2

GENE ID SPECIES
452022 Pan troglodytes
553455 Danio rerio
715555 Macaca mulatta
100172483 Pongo abelii
216440 Mus musculus
362891 Rattus norvegicus
10956 Homo sapiens
474419 Canis lupus familiaris
504832 Bos taurus
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