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anti-Otoferlin (OTOF) Antibodies

Mutations in OTOF are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OTOF 9381 Q9HC10
OTOF 83762 Q9ESF1
OTOF 84573  
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Top anti-Otoferlin Antibodies at

Showing 10 out of 16 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p) 50 μg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated IHC (p), WB Anti- Otoferlin Picoband antibody,IHC(P) IHC(P): Mouse Brain Tissue Observed bind size: 227KD 100 μg Log in to see 4 to 6 Days
Mouse Rabbit Un-conjugated IHC Immunostaining of cochlear inner hair cells (IHCs) from p17 C57black mouse. Fixation was performed in 4 % PFA for one hour. Immunoreactivity was revealed by indirect immunofluorescence using an Alexa-488 labeled secondary antibody. 50 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Otoferlin Antibody [NBP1-85234] - Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes. 0.1 mL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated IHC, ELISA 0.05 mg Log in to see 2 to 3 Days
Human Mouse Un-conjugated ICC, IP, WB   100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated IHC, IHC (p), WB Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-46574] - Rat cerebellum. Dilution 1: 1000. Immunohistochemistry-Paraffin: Otoferlin Antibody [NBP1-46574] - Rat spinal cord, dilution 1: 1000. 0.1 mL Log in to see 12 to 15 Days
Human Rabbit Un-conjugated IHC (p), ELISA Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with OTOF antibody ABIN214001 at 20 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
Human Mouse Un-conjugated ELISA, FACS, IF, IHC, IP, WB   100 μg Log in to see 5 to 6 Days
Human Rabbit Un-conjugated IHC (p), ELISA 50 μg Log in to see 11 to 13 Days

OTOF Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , ,
Mouse (Murine) ,
Rat (Rattus)

Top referenced anti-Otoferlin Antibodies

  1. Mouse (Murine) Polyclonal Otoferlin Primary Antibody for IHC - ABIN1742371 : Vogl, Cooper, Neef, Wojcik, Reim, Reisinger, Brose, Rhee, Moser, Wichmann: Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. in Journal of cell science 2015 (PubMed)

More Antibodies against Otoferlin Interaction Partners

Human Otoferlin (OTOF) interaction partners

  1. Mutations in RAI1 (show DOM3Z Antibodies), OTOF, and SLC26A4 (show SLC26A4 Antibodies) may have roles in nonsyndromic hearing loss in Altaian families in Siberia

  2. Our observation of the discordant audiologic phenotype within the same DFNB9 family is more likely due to the loss of OAE over time rather than a genotype-phenotype correlation.

  3. audiological phenotype associated with different OTOF mutations appears to be consistently different suggesting the presence of a genotype-phenotype correlation

  4. The C2F (show EMG1 Antibodies) and C2C domains of otoferlin preferentially bind phosphatidylinositol 4,5-bisphosphate (4,5)P2.

  5. We characterize a novel otoferlin mutation discovered in a sibling pair diagnosed with auditory neuropathy spectrum disorder and investigate auditory nerve function through their cochlear implants.

  6. OTOF gene mutataion is found in a Chinese patient with auditory neuropathy spectrum disorder.

  7. The six probable pathogenic variants of OTOF genes were novel: 2 nonsense mutations (p.W717X, p.S1368X) and 4 missense mutations (p.D450E, p.R1583H, p.V1778I, p. E1803A).

  8. Data indicate that dysferlin (show DYSF Antibodies), otoferlin, and myoferlin (show MYOF Antibodies) do not merely passively adsorb to membranes but actively sculpt lipid bilayers.

  9. The study concludes that OTOF mutations are not the major cause of autosomal recessive nonsyndromic hearing loss in the Iranian population.

  10. nine different mutations of OTOF were detected(seven of them were novel)in Japanese patients with auditory neuropathy

Mouse (Murine) Otoferlin (OTOF) interaction partners

  1. Furthermore, this F-actin mesh network attached to the synaptic ribbons directly influences the efficiency of otoferlin-dependent exocytosis and its sensitivity to intracellular hydrostatic pressure.

  2. Mice that carry a mutation in a calcium binding domain of Otoferlin, the putative calcium sensor at hair cell synapses, have normal distortion product otoacoustic emissions (DPOAEs), but auditory brain stem responses (ABRs) are absent.

  3. a direct role for otoferlin in exocytosis and modulation of calcium-dependent membrane fusion

  4. The analysis of otoferlin knockout mice gave the 1st insights into its function in inner hair cell calcium-dependent exocytosis & type-i vestibular hair cells. Review.

  5. Co-localization studies revealed an overlap of Ergic2 (show ERGIC2 Antibodies) and Otoferlin signals in IHCs and neurons of cerebral cortical layer I making Ergic2 (show ERGIC2 Antibodies) the promising binding candidate

  6. Otoferlin deletion does not affect transmitter release at hippocampal synapses.

  7. Otoferlin is a calcium sensor that can directly regulate soluble N-ethyl-maleimide sensitive fusion protein attachment protein receptor-mediated membrane fusion reactions.

  8. Otoferlin underlies highly efficient calcium ion-dependent membrane fusion, a process likely essential to increase the probability and synchrony of vesicle fusion events at the mature inner hair cell ribbon synapse.

  9. Deficient vesicle replenishment underlies the hearing impairment of Otof(Pga/Pga) mice. Otoferlin may confer the high capacity for vesicle re-supply to the inner hair cell synapse.

  10. Otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2 (show CA2 Antibodies)+) sensor triggering membrane fusion at the auditory inner hair cell ribbon synapse.

Otoferlin (OTOF) Antigen Profile

Protein Summary

Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has 3 C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has 6 C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multiple isoforms have been found for this gene.

Gene names and symbols associated with anti-Otoferlin (OTOF) Antibodies

  • otoferlin (OTOF) antibody
  • otoferlin (AaeL_AAEL014853) antibody
  • otoferlin (CpipJ_CPIJ002471) antibody
  • otoferlin (CpipJ_CPIJ010863) antibody
  • otoferlin (Smp_163750) antibody
  • otoferlin (otof) antibody
  • otoferlin (Otof) antibody
  • AUNB1 antibody
  • DFNB6 antibody
  • DFNB9 antibody
  • FER1L2 antibody
  • fj34b10 antibody
  • NSRD9 antibody
  • Otof antibody
  • si:dkey-181f18.3 antibody
  • wu:fj34b10 antibody

Protein level used designations for anti-Otoferlin (OTOF) Antibodies

otoferlin , fer-1-like protein 2 , otoferlin transcript variant 46-48

422007 Gallus gallus
607961 Canis lupus familiaris
617299 Bos taurus
5565414 Aedes aegypti
6033654 Culex quinquefasciatus
6043387 Culex quinquefasciatus
8355726 Schistosoma mansoni
100125064 Xenopus (Silurana) tropicalis
100329046 Saccoglossus kowalevskii
100479400 Ailuropoda melanoleuca
100596202 Nomascus leucogenys
9381 Homo sapiens
83762 Mus musculus
84573 Rattus norvegicus
557476 Danio rerio
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