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Required for normal formation of otoconia in the inner ear. Additionally we are shipping Otopetrin 1 Antibodies (22) and many more products for this protein.
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Otop1 defines a unique target of cytokine signaling that attenuates obesity-induced adipose tissue inflammation and plays an adaptive role in maintaining metabolic homeostasis in obesity.
Data show that tlt and mlh mutations uncouple Otopetrin 1 from inhibition of P2Y (show P2RY1 Proteins) receptor function.
OTOP1 is expressed at the apex (show APEX1 Proteins) of supporting cells. It increases cytosolic Ca in response to purinergic agonists by blocking mobilization of Ca from intracellular stores in an extracellular Ca-dependent manner & by mediating extracellular Ca influx.
Otopetrin 1 encodes a multi-transmembrane domain protein expressed in the developing otocyst. Mouse mutants tilted and mergulhador carry recessive mutations in Otop1 that result in otoconial agenesis without causing collateral deafness.
Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP (By similarity).