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OLR1 encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. Additionally we are shipping OLR1 Kits (78) and OLR1 Proteins (27) and many more products for this protein.
Showing 10 out of 222 products:
Human Polyclonal OLR1 Primary Antibody for IF (p), IHC (p) - ABIN676988
Wu, Tang, Jiang, Li, Jiang, Liu: PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. in Molecular and cellular biochemistry 2011
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Human Polyclonal OLR1 Primary Antibody for IHC (fro), FACS - ABIN2475355
Sawamura, Kume, Aoyama, Moriwaki, Hoshikawa, Aiba, Tanaka, Miwa, Katsura, Kita, Masaki: An endothelial receptor for oxidized low-density lipoprotein. in Nature 1997
Show all 4 Pubmed References
Human Polyclonal OLR1 Primary Antibody for IF, ELISA - ABIN2475353
Chen, Masaki, Sawamura: LOX-1, the receptor for oxidized low-density lipoprotein identified from endothelial cells: implications in endothelial dysfunction and atherosclerosis. in Pharmacology & therapeutics 2002
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Human Polyclonal OLR1 Primary Antibody for IF, ELISA - ABIN2475354
Li, Liu, Chen, Sawamura, Mehta: LOX-1, an oxidized LDL endothelial receptor, induces CD40/CD40L signaling in human coronary artery endothelial cells. in Arteriosclerosis, thrombosis, and vascular biology 2003
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Mouse (Murine) Monoclonal OLR1 Primary Antibody for FACS - ABIN4897693
Biedroń, Konopiński, Marcinkiewicz, Józefowski: Oxidation by neutrophils-derived HOCl increases immunogenicity of proteins by converting them into ligands of several endocytic receptors involved in antigen uptake by dendritic cells and macrophages. in PLoS ONE 2015
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Human Polyclonal OLR1 Primary Antibody for ELISA - ABIN1997147
Hinagata, Kakutani, Fujii, Naruko, Inoue, Fujita, Mehta, Ueda, Sawamura: Oxidized LDL receptor LOX-1 is involved in neointimal hyperplasia after balloon arterial injury in a rat model. in Cardiovascular research 2005
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Human Polyclonal OLR1 Primary Antibody for ICC, IF - ABIN4331395
Chen, Qiu, Lin, Nam, Ogbu-Nwobodo, Archibald, Joslin, Wun, Sawamura, Green: Lectin-like oxidized low-density lipoprotein receptor (LOX-1) in sickle cell disease vasculopathy. in Blood cells, molecules & diseases 2016
Human Polyclonal OLR1 Primary Antibody for ELISA, WB - ABIN4331396
Shi, Cosentino, Camici, Akhmedov, Vanhoutte, Tanner, Lüscher: Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells. in Arteriosclerosis, thrombosis, and vascular biology 2011
ox-LDL and LOX-1 increase due to subarachnoid hemorrhage and they may play a role in the pathogenesis of vasospasm.
LOX (show LOX Antibodies) and LOXL2 (show LOXL2 Antibodies) play an important role in wound healing after glaucoma filtration surgery. Targeting LOXL2 (show LOXL2 Antibodies) with an inhibitory monoclonal antibody (GS-607601) had a broader efficacy than targeting LOX (show LOX Antibodies), reducing angiogenesis and inflammation, and fibrosis.
Angiotensin (1-7) inhibited LOX-1 expression and diminished Ang II (show AGT Antibodies)-mediated inflammation in endothelial cells
Elevated LOX-1 expression and inflammatory responses are induced in hypercholesterolemic rabbits by Chlamydia pneumoniae GroEL1 heat shock protein.
Early treatment with fluvastatin had a crucial endothelial protective effect by down-regulating LOX-1 expression level in atherosclerotic arteries in early atherosclerosis.
LOX-1 expression appears to be closely associated with tissue factor (show F3 Antibodies) expression, apoptotic events and morphological vulnerability in atherosclerotic lesions
LOX-1 signalling and the crucial role of cytokines
High OLR1 expression is associated with breast cancer.
Multiple classical molecular dynamics simulations have been applied to the human LOX-1 receptor to clarify the role of the Trp150Ala mutation in the loss of binding activity. Results indicate that the substitution of this crucial residue, located at the dimer interface, markedly disrupts the wild-type receptor dynamics
Carrying the C allele of the rs11053646 variant of the OLR1 gene was associated with an increased risk of CAD (show CAD Antibodies) in heterozygous adult patients with FH, and this risk could be even greater in smokers as well as in younger patients.
Berberine could prevent the oxLDL and TNFalpha (show TNF Antibodies) - induced LOX1 expression and oxidative stress, key events that lead to NOX, MAPK (show MAPK1 Antibodies)/Erk1/2 (show MAPK1/3 Antibodies) and NF-kappaB (show NFKB1 Antibodies) activation linked to endothelial dysfunction.
Data suggest Klotho (show KL Antibodies) attenuates ox-LDL- (oxidized low density lipoprotein)-induced oxidative stress in vascular endothelial cells via up-regulation of oxidative scavengers (lipoprotein and nitric oxide), activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies)/eNOS (show NOS3 Antibodies) signaling, and down-regulation of LOX1 (lectin-like ox-LDL receptor (show LDLR Antibodies)) expression. (PI3K (show PIK3CA Antibodies) = phosphatidylinositol 3-Kinase; Akt (show AKT1 Antibodies) = proto-oncogene c-Akt (show AKT1 Antibodies); eNOS (show NOS3 Antibodies) = endothelial nitric oxide synthase (show NOS3 Antibodies))
Individuals >/=30 years old with abdominal obesity presented lower Lox1 levels than patients >/=30 years old without abdominal obesity.
These studies suggest that activation of LOX-1 expression occurs through binding of the chlamydial glycan and provides one mechanism by which Chlamydia pneumoniae infection could play a role in the pathogenesis of atherosclerosis.
Elevated LOX1 is Associated with Acute Stroke.
Xanthine oxidase (show XDH Antibodies) induces foam cell formation in large part through activation of LOX-1 - NLRP3 (show NLRP3 Antibodies) pathway in both vascular smooth muscle cells and THP-1 (show GLI2 Antibodies) cells.
At low oxLDL levels LOX-1 activates the protective Oct-1 (show POU2F1 Antibodies)/SIRT1 (show SIRT1 Antibodies) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (show MAPK1/3 Antibodies) pathway.
The findings suggested that ox-LDL could induce cardiac hypertrophy through the direct association of AT1-R (show AGTR1 Antibodies) and LOX-1.
Adiponectin, TNF-alpha (show TNF Antibodies), and LOX-1 exert complex regulatory effects on the coronary microvascular endothelial function in atherosclerotic ApoE (show APOE Antibodies) knockout mice.
LOX-1 in cardiomyocytes plays an important role in the pathology of doxorubicin-induced cardiomyopathy. LOX-1 deletion altered the LOX-1-related signaling pathway, which led to improvements in cardiac function, myocardial inflammation, fibrosis and degenerative changes after DOX treatment.
Therefore we concluded that HNG (show NRGN Antibodies) could inhibit ox-LDL-induced macrophage-derived foam cell formation, which occurs because of a decrease in lipid uptake and an increase in cholesterol efflux from macrophage cells.
The study indicated that the LOX-1/ox-LDL system in chondrocytes plays a role in the pathogenesis of age-related knee knee osteoarthritis, which is potentially a target for preventing knee osteoarthritis progression.
We demonstrated that varenicline upregulates expression of LOX-1 and CD36 (show CD36 Antibodies) significantly through alpha7 nAChR (show CHRNA7 Antibodies), thereby promoting oxLDL uptake in macrophages.
this study shows that LOX-1 can regulate inflammation through regulation of generation of reactive oxygen species in in Aspergillus fumigatus keratitis
The in vitro and in vivo models revealed that lipid metabolism disorder and FK506 caused oxidative stress and a fibrogenic response. In addition, decreased levels of LOX1 markedly reduced the levels of TGFb1 (show TGFB1 Antibodies) in the in vitro model.
LOX-1/ox-LDL system plays a pivotal role in the pathogenesis of instability-induced osteoarthritis through endochondral ossification.
bta-miR (show MYLIP Antibodies)-370 has a negative regulatory effect on the OLR1 gene at both the gene and protein expression levels and has a role in lipid metabolism in bovine adipocytes
Overexpression of LOX-1 leads to the attenuation of protective autophagy response in aortic endothelial cells.
These results imply that the 3' UTR (show UTS2R Antibodies) SNP of the OLR1 gene is a strong candidate marker for selection in cattle breeding programs.
Our data indicate that blocking the LOX-1 receptor signal pathway might be a promising way to improve steroid hormone concentrations in metabolically highly active female mammals
In the present study, we show that inhibition of LOX-1 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus
The downregulation of eNOS (show NOS3 Antibodies) by ox-low-density lipoprotein, as driven by LOX-1-mediated endoplasmic stress, is associated with the PI3K-Akt (show AKT1 Antibodies)-eNOS (show NOS3 Antibodies) signaling pathway.
3'-UTR (show UTS2R Antibodies) SNP assoicated with milk composition traits and somatic cell score
Oxidized low-density lipoprotein receptor (show LDLR Antibodies) (OLR1) single nucleotide polymorphism haplotype is associated with milk fat yield and fat percentage
synergistic effects of cyclic tensile stretch load and ox-LDL on cell viability and proteoglycan (show Vcan Antibodies) synthesis in chondrocytes, which may be mediated through enhanced expression of LOX-1
Upregulates VEGF (show VEGFA Antibodies) expression in articular cartilage, at least in part, through activation of PPAR-gamma (show PPARG Antibodies).
This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.
oxidised low density lipoprotein (lectin-like) receptor 1
, oxidized low density lipoprotein (lectin-like) receptor 1
, lectin-like oxLDL receptor 1
, lectin-like oxidized LDL receptor 1
, lectin-type oxidized LDL receptor 1
, ox-LDL receptor 1
, oxidized low-density lipoprotein receptor 1
, C-type lectin domain family 8 member A
, ox LDL receptor 1
, oxidized low-density lipoprotein receptor 1, soluble form
, scavenger receptor class E, member 1
, Lectin-like oxidized low-density lipoprotein receptor-1
, lectin-like oxidized low-density lipoprotein receptor
, lectin-like oxidized LDL receptor-1
, oxidized low density lipoprotein receptor 1