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OSBPL2 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 2 Antibodies (31) and Oxysterol Binding Protein-Like 2 Proteins (5) and many more products for this protein.
Bioinformatics analysis indicates that zebrafish has two homologues of Osbpl2 gene (Osbpl2a and Osbpl2b) which have different expression patterns during embryonic development.
a novel role for ORP2 in regulating steroidogenic capacity and cholesterol homeostasis in the adrenal cortex
This study and the recent description of another frameshift mutation in a Chinese ADNSHL family identify OSBPL2 as a novel gene for progressive deafness.
Results identified frameshift and missense mutation in OSBPL2 gene in familial and sporadic case of deafness suggesting OSBPL2 as a novel candidate gene for autosomal dominant nonsyndromic hearing loss .
Complexes of human ORP2 and VAPs at endoplasmic reticulum-lipid droplet interfaces regulate the hydrolysis of triglycerides and lipid droplet turnover.
ORP2 as a novel regulator of cellular sterol homeostasis and intracellular membrane trafficking.
Results identify ORP2 as a sterol receptor present on LD and provide evidence for its role in the regulation of neutral lipid metabolism, possibly as a factor that integrates the cellular metabolism of triglycerides with that of cholesterol.
The regulation of OSBPL2 by Mir96 was investigated in Mir96 mutant mice.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
oxysterol binding protein-like 1A
, oxysterol binding protein-like 2
, oxysterol-binding protein-related protein 2
, oxysterol-binding protein-like protein 2
, oxysterol-binding protein-related protein 2-like
, OSBP-related protein 2
, oxysterol-binding protein-like 2