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Oxysterol Binding Protein-Like 8 Proteins (OSBPL8)

OSBPL8 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 8 Antibodies (13) and Oxysterol Binding Protein-Like 8 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat OSBPL8 OSBPL8 314824  
OSBPL8 114882 Q9BZF1
OSBPL8 237542  
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Top Oxysterol Binding Protein-Like 8 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

OSBPL8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Oxysterol Binding Protein-Like 8 (OSBPL8) Interaction Partners

Human Oxysterol Binding Protein-Like 8 (OSBPL8) interaction partners

  1. ORP5 (show OSBPL5 Proteins) and ORP8 could mediate PI4P/phosphatidylserine (PS) countertransport between the endoplasmic reticulum (ER) and the plasma membrane (PM), thus delivering PI4P to the ER-localized PI4P phosphatase Sac1 (show SACM1L Proteins) for degradation and PS from the ER to the PM.

  2. role of ORP8 in Fas (show FAS Proteins) translocation to the plasma membrane and its down-regulation by miR (show MLXIP Proteins)-143 offer a putative mechanistic explanation for HCC (show FAM126A Proteins) resistance to apoptosis

  3. Data indicate that miR (show MLXIP Proteins)-143 impairs insulin (show INS Proteins) action via downregulation of oxysterol-binding protein-related protein 8 (ORP8).

  4. ORP8 overexpression resulted in reduced expression of the aP2 (show GTF3A Proteins) mRNA, while down-regulation of adiponectin (show ADIPOQ Proteins) and aP2 (show GTF3A Proteins) was observed in ORP11 (show OSBPL11 Proteins) silenced cells. ORP8 overexpression or silencing of ORP11 (show OSBPL11 Proteins) markedly decreased cellular triglyceride storage.

  5. results reveal that ORP8 has the capacity to modulate lipid homeostasis and SREBP activity, probably through an indirect mechanism, and provide clues of an entirely new mode of ORP action

  6. Data identify ORP8 as a negative regulator of ABCA1 (show ABCA1 Proteins) expression and macrophage cholesterol efflux. ORP8 may, thus, modulate the development of atherosclerosis.

Mouse (Murine) Oxysterol Binding Protein-Like 8 (OSBPL8) interaction partners

  1. Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor (show LDLR Proteins) knockout mice.

  2. Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.

  3. aspects of ORP8 function in macrophages not directly involving lipid metabolism, but rather associated with nuclear functions, microtubule organization, and migration capacity

Oxysterol Binding Protein-Like 8 (OSBPL8) Protein Profile

Protein Summary

This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with OSBPL8

  • oxysterol binding protein-like 8 (Osbpl8)
  • oxysterol binding protein-like 8 (OSBPL8)
  • oxysterol binding protein-like 8 (osbpl8)
  • AA536976 protein
  • AA536995 protein
  • C730029P18Rik protein
  • D330025H14Rik protein
  • DKFZp469P0923 protein
  • MST120 protein
  • MSTP120 protein
  • ORP-8 protein
  • ORP8 protein
  • OSBP10 protein
  • RGD1561474 protein

Protein level used designations for OSBPL8

oxysterol-binding protein-related protein 8 , oxysterol binding protein-like 8 , oxysterol-binding protein-like protein 8 , oxysterol-binding protein-related protein 8-like , ORP-8 , OSBP-related protein 8

GENE ID SPECIES
314824 Rattus norvegicus
417866 Gallus gallus
446929 Xenopus laevis
452085 Pan troglodytes
693338 Macaca mulatta
100018363 Monodelphis domestica
100059086 Equus caballus
100145444 Xenopus (Silurana) tropicalis
100172591 Pongo abelii
100175952 Ciona intestinalis
100218984 Taeniopygia guttata
100356792 Oryctolagus cuniculus
100484438 Ailuropoda melanoleuca
100525288 Sus scrofa
100566303 Anolis carolinensis
100595122 Nomascus leucogenys
100409878 Callithrix jacchus
114882 Homo sapiens
475408 Canis lupus familiaris
533350 Bos taurus
237542 Mus musculus
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