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OSBPL6 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 6 Proteins (6) and many more products for this protein.
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family-based GWAS of imputed SNPs revealed novel genomic variants in (or near) PTPRG (show PTPRG Antibodies), OSBPL6, and PDCL3 (show PDCL3 Antibodies) that influence risk for Alzheimer's Disease. rs7609954 in the gene PTPRG (show PTPRG Antibodies), rs1347297 in the gene OSBPL6, and rs1513625 near PDCL3 (show PDCL3 Antibodies). In addition, rs72953347 in OSBPL6 and two SNPs in the gene CDKAL1 (show CDKAL1 Antibodies) showed marginally significant association with LOAD (rs10456232, P-value=4.76 x 10-7; rs62400067, P-value=3.54 x 10-7).
Oxysterol-binding protein-like 6 is a novel regulator of cholesterol trafficking that is part of the miR (show MLXIP Antibodies)-33 and miR (show MLXIP Antibodies)-27b target gene networks contributing to the maintenance of cholesterol homeostasis.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified.
, OSBP-related protein 6
, oxysterol-binding protein-related protein 6