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The protein encoded by PAK7 is a member of the PAK family of Ser/Thr protein kinases. Additionally we are shipping PAK7 Antibodies (95) and many more products for this protein.
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PAK7 is overexpressed in human esophageal squamous cell cancer samples and correlated with lymph node metastasis.
E47 (show TCF3 Proteins) is a novel substrate of PAK5 (show PAK6 Proteins), and PAK5 (show PAK6 Proteins)-mediated phosphorylation of E47 (show TCF3 Proteins) promotes epithelial-mesenchymal transition and metastasis of colon cancer.
Aurora-A induced PAK7 expression in esophageal cancer cells.
results suggest that the inhibition of PAK5 by RNA interference might efficiently suppress tumor development of glioma cells with PAK5 high expression.
miR-129 suppresses tumor cell growth and invasion by targeting PAK5 in hepatocellular carcinoma.
PAK7 promotes cell proliferation and tumorigenesis
It inhibits glioma cell migration and invasion potentially through the PAK5 (show PAK6 Proteins)-Egr1 (show EGR1 Proteins)-MMP2 (show MMP2 Proteins) signaling pathway.
PAK5 functions as an oncogenic kinase in tumor cellular regulation
Results demonstrate that PAK7 is developmentally co-expressed with another known psychosis risk gene (DISC1 (show DISC1 Proteins)) suggesting a potential molecular mechanism involving aberrant synapse development and plasticity.
PAK5 is correlated to human epithelial ovarian cancer (EOC) and increased PAK5 expression promotes EOC progression.
PAK-7 p21-activated kinase 5 knockout mice are more sensitive to the stimulant effects of amphetamine
functional deficits in PAK5, PAK6 (show PAK6 Proteins) and PAK5/PAK6 (show PAK6 Proteins) knockout mice
PAK 5 is involved in formalin-induced inflammatory nociception through regulation of MAPK-induced c-Fos-activation and formalin-specific transient receptor potential-channels.
These results implicate Pak5 in Pacsin1 (show PACSIN1 Proteins)- and Synaptojanin1-mediated synaptic vesicle trafficking.
PAK5 may provide a molecular rationale for late-stage complications in diabetes.
Our results indicate that Pak5 and Pak6 (show PAK6 Proteins) together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described.
, p21(CDKN1A)-activated kinase 7
, p21-activated kinase 5
, p21-activated kinase 7
, p21CDKN1A-activated kinase 7
, protein kinase PAK5
, serine/threonine-protein kinase PAK 7
, serine/threonine-protein kinase PAK7
, p21 (CDKN1A)-activated kinase 7