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PAK6 encodes a member of a family of p21-stimulated serine\\/threonine protein kinases, which contain an amino-terminal Cdc42\\/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. Additionally we are shipping P21-Activated Kinase 6 Antibodies (148) and P21-Activated Kinase 6 Proteins (6) and many more products for this protein.
p21-activated kinase 6 (PAK6) as a novel interactor of leucine-rich repeat kinase 2 (LRRK2 (show LRRK2 ELISA Kits)), a kinase involved in Parkinson's disease
PAK6 is directly targeted by miR (show MLXIP ELISA Kits)-328. miR (show MLXIP ELISA Kits)-328 inhibits cell growth and promotes cell apoptosis in prostate cancer cells.
negative correlation between PAK6 and EZH2 (show EZH2 ELISA Kits) expression was observed in hepatoma tissues from HCC (show FAM126A ELISA Kits) patients. These data identified the tumor suppressive role and potential underlying mechanism of PAK6 in hepatocarcinogenesis
the results of the present study suggested that miR (show MLXIP ELISA Kits)-429 inhibits the migration and invasion of colon cancer cells, partly at least, by mediating the expression of PAK6, as well as the activity of cofilin (show CFL1 ELISA Kits) signaling
we report that in colon cancer PAK6 promotes tumor progression and chemoresistance both in vitro and in vivo
PAK6 is specifically required for carcinoma cell-cell dissociation downstream of hepatocyte growth factor (HGF (show HGF ELISA Kits)) for both DU145 prostate cancer and HT29 colon cancer cells.
PAK5 plays an essential role in the initiation and progression of hepatocellular carcinoma.
These results demonstrate that androgen-stimulated PAK6 activation is mediated through a direct interaction between AR and PAK6 and PAK6 activation promotes prostate cancer cells motility and invasion.
PAK6 is overexpressed in hepatocellular carcinoma, compared with the adjacent noncancerous liver tissues, and is associated with poor prognosis.
PAK6 phosphorylates Mdm2 on Thr-158 and Ser-186, which is critical for AR ubiquitin-mediated degradation.
data suggest that PAK-6 p21-activated kinase plays a role in weight gain unrelated to exercise and caloric intake
functional deficits in PAK5 (show PAK7 ELISA Kits), PAK6 and PAK5/PAK6 knockout mice
Our results indicate that Pak5 (show PAK7 ELISA Kits) and Pak6 together are not required for viability, but are required for a normal level of locomotion and activity as well as for learning and memory.
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants.
p21 protein (Cdc42/Rac)-activated kinase 6
, p21-activated kinase 6
, serine/threonine-protein kinase PAK 6
, p21(CDKN1A)-activated kinase 6
, p21 (CDKN1A)-activated kinase 6