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PAK1/2/3 encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins.
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Human Polyclonal PAK1/2/3 Primary Antibody for IHC - ABIN966798
Parsons, Monypenny, Ameer-Beg, Millard, Machesky, Peter, Keppler, Schiavo, Watson, Chernoff, Zicha, Vojnovic, Ng: Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. in Molecular and cellular biology 2005
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Human Polyclonal PAK1/2/3 Primary Antibody for IF, IHC - ABIN362174
Jung, Traugh: Regulation of the interaction of Pak2 with Cdc42 via autophosphorylation of serine 141. in The Journal of biological chemistry 2005
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Human Polyclonal PAK1/2/3 Primary Antibody for IF, IHC - ABIN362788
Lampugnani, Zanetti, Breviario, Balconi, Orsenigo, Corada, Spagnuolo, Betson, Braga, Dejana: VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. in Molecular biology of the cell 2002
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Human Polyclonal PAK1/2/3 Primary Antibody for IHC - ABIN966799
Wang, Mazumdar, Vadlamudi, Kumar: P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. in The EMBO journal 2002
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results represent the first evidence that Pak1 (show PAK1 Antibodies) links extracellular signals to the genetic cascade of transcription factors necessary for cranial neural crest specification
These findings expand the role of phosphoinositides in kinase signaling and suggest how altered phosphoinositide metabolism may upregulate Pak1 (show PAK1 Antibodies) activity in cancer cells.
The data suggest that EphA4 activation sequesters active Cdc42 (show CDC42 Antibodies) and in this way down-regulates cell-cell adhesion.
Pak1 (show PAK1 Antibodies) inhibition interferes with the guidance of mesendoderm migration by directional cues residing in the extracellular matrix of the blastocoel roof, and with mesendoderm translocation in the embryo.
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
p21 GTPase-associated kinase 1
, p21-activated kinase 1
, p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
, putative CDKN1A-activated kinase 1