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PAP Associated Domain Containing 4 Proteins (PAPD4)

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Additionally we are shipping PAP Associated Domain Containing 4 Antibodies (24) and PAP Associated Domain Containing 4 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAPD4 167153 Q6PIY7
PAPD4 100715 Q91YI6
Rat PAPD4 PAPD4 361878 Q5U315
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Top PAP Associated Domain Containing 4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,367.83
Details
Yeast Zebrafish His tag   1 mg Log in to see 56 to 66 Days
$3,384.33
Details

PAPD4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for PAP Associated Domain Containing 4 (PAPD4) Interaction Partners

Human PAP Associated Domain Containing 4 (PAPD4) interaction partners

  1. QKI (show QKI Proteins)-7 recruits PAPD4 to regulate post-transcriptional polyadenylation of target mRNAs.

  2. HBx is a critical protein derived from HBV, which regulates miR (show MLXIP Proteins)-122 via down-regulating Gld2

  3. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR (show MLXIP Proteins)-122, possibly through catalyzing 3' monoadenylation

  4. Study identified TUT7, TUT4 (show ZCCHC11 Proteins), and TUT2 as novel components of the miRNA biogenesis pathway.

  5. poly(A) polymerase (show PAPOLA Proteins) Gld2, deadenylase PARN (show PARN Proteins), and translation inhibitory factor neuroguidin (Ngd (show NGDN Proteins)) are components of a dendritic CPEB (show CPEB1 Proteins)-associated polyadenylation apparatus

  6. human CPE-binding protein 1 (show CPEB1 Proteins) and hGLD-2 are antagonizing factors regulating p53 (show TP53 Proteins) mRNA stability.

  7. The authors show that the human CPEB1 (show CPEB1 Proteins) can repress the activity of the reporter construct containing the HPV-16 early sequences. This repression can be counteracted by a human cytoplasmic poly(A) polymerase, hGLD-2 fused to CPEB1 (show CPEB1 Proteins).

Mouse (Murine) PAP Associated Domain Containing 4 (PAPD4) interaction partners

  1. poly(A) polymerase (show PAPOLA Proteins) Gld2, deadenylase PARN (show PARN Proteins), and translation inhibitory factor neuroguidin (Ngd (show NGDN Proteins)) are components of a dendritic CPEB (show CPEB1 Proteins)-associated polyadenylation apparatus

  2. We found an association of mGLD-2 with cytoplasmic polyadenylation components, CPEB (show CPEB1 Proteins) and CPSF (show CPSF2 Proteins) described in Xenopus oocytes

  3. mGLD-2 may act in the ooplasm on the progression of metaphase I to metaphase II during oocyte maturation.

  4. identified GLD-2, which is a regulatory cytoplasmic poly(A) polymerase, as responsible for the 3'-terminal adenylation of miR (show MLXIP Proteins)-122 after unwinding of the miR (show MLXIP Proteins)-122/miR (show MLXIP Proteins)-122* duplex

Caenorhabditis elegans (C. elegans) PAP Associated Domain Containing 4 (PAPD4) interaction partners

  1. GLD-2 thus appears to have evolved specialized nucleotidyl-transferase properties that match the 3' end features of dormant cytoplasmic mRNAs

  2. The analyses suggest that GLD-2 activity mediates mRNA stability of many translationally repressed mRNAs.

  3. Data suggest that the FBF-2/GLD-2 protein directed polyadenylation of the endogenous mRNA, compensating for that mRNA's natural deadenylation.

  4. Data suggest that the GLD-2/RNP (show RNPC3 Proteins)-8 enzyme is a broad-spectrum regulator of the oogenesis program that acts within an RNA regulatory network to specify and produce fully functional oocytes.

  5. Regulates Gld-1 messenger RNA in germ cells, enabling the transition from mitosis to meiosis.

  6. FBF can affect polyadenylation either negatively by its CCF-1 interaction or positively by its GLD-2 interaction in control of GLD1 expression.

  7. GLD-4 is predominantly expressed in germ cells, and its activity is essential for early meiotic progression of male and female gametes in the absence of GLD-2

  8. In C. elegans hermaphrodites, gamete production begins with spermatogenesis and transitions later to oogenesis; the combinatorial use of GLD-2 contributes to this transition, as GLD-2/GLD-3 promotes spermatogenesis, and GLD-2/RNP (show RNPC3 Proteins)-8 specifies oogenesis.

PAP Associated Domain Containing 4 (PAPD4) Protein Profile

Protein Summary

Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. Acts as a regulator of mitosis/meiosis required for progression through meiotic prophase during oogenesis and spermatogenesis and for promotion of the entry into meiosis from the mitotic cell cycle. May act by regulating and activating gld-1 mRNA activity in germ line.

Gene names and symbols associated with PAPD4

  • PAP associated domain containing 4 (PAPD4)
  • PAP associated domain containing 4 (Papd4)
  • PAP associated domain containing 4 (papd4)
  • Protein GLD-2 (gld-2)
  • 8030446C20Rik protein
  • AI649009 protein
  • GLD-2 protein
  • Gld2 protein
  • zgc:110560 protein

Protein level used designations for PAPD4

PAP-associated domain-containing protein 4 , TUTase 2 , hGLD-2 , poly(A) RNA polymerase GLD2 , terminal uridylyltransferase 2 , cytoplasmic poly(A) polymerase , mGLD-2 , TUTase2

GENE ID SPECIES
167153 Homo sapiens
607764 Canis lupus familiaris
533862 Bos taurus
100715 Mus musculus
361878 Rattus norvegicus
553626 Danio rerio
172338 Caenorhabditis elegans
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