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anti-PARG (PARG) Antibodies

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Additionally we are shipping PARG Proteins (5) and PARG Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PARG 8505 Q86W56
Anti-Mouse PARG PARG 26430  
Anti-Rat PARG PARG 83507 Q9QYM2
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Top anti-PARG Antibodies at antibodies-online.com

Showing 10 out of 37 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with Parg antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of Parg (arrow) using rabbit polyclonal Parg Antibody (C-term) . 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Parg gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of Parg Antibody (C-term) in 293 cell line lysates (35 µg/lane). Parg (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of Parg (arrow) using rabbit polyclonal Parg Antibody (C-term) (ABIN391439).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the Parg gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of PARG Antibody (C-term) in NCI-H292 cell line lysates (35ug/lane). This demonstrates the PARG antibody detected the PARG protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-PARG AntibodyTitration: 1.0 µg/mL  Positive Control: Jurkat Whole Cell 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB PARG Antibody (C-term)  western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PARG antibody detected the PARG protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Western Blot analysis of PARG expression in transfected 293T cell line by PARG MaxPab polyclonal antibody.Lane 1: PARG transfected lysate(107.36 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of purified MaxPab antibody to PARG on HeLa cell. [antibody concentration 10 ug/ml] 50 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit PE ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 400 μL Log in to see 6 Days
$457.14
Details
Human Rabbit Un-conjugated ELISA   200 μL Log in to see 8 to 10 Days
$713.17
Details

PARG Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human ,
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Top referenced anti-PARG Antibodies

  1. Human Polyclonal PARG Primary Antibody for EIA, WB - ABIN953994 : Whatcott, Meyer-Ficca, Meyer, Jacobson: A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. in Experimental cell research 2009 (PubMed)
    Show all 5 references for ABIN953994

  2. Human Polyclonal PARG Primary Antibody for IHC (p), WB - ABIN391439 : Meyer, Meyer-Ficca, Whatcott, Jacobson, Jacobson: Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. in Experimental cell research 2007 (PubMed)
    Show all 3 references for ABIN391439

  3. Human Polyclonal PARG Primary Antibody for EIA, IHC (p) - ABIN359530 : Fisher, Hochegger, Takeda, Caldecott: Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. in Molecular and cellular biology 2007 (PubMed)
    Show all 3 references for ABIN359530

  4. Human Polyclonal PARG Primary Antibody for IF, WB - ABIN521952 : Boudra, Bolin, Chiker, Fouquin, Zaremba, Vaslin, Biard, Cordelières, Mégnin-Chanet, Favaudon, Fernet, Pennaneach, Hall: PARP-2 depletion results in lower radiation cell survival but cell line-specific differences in poly(ADP-ribose) levels. in Cellular and molecular life sciences : CMLS 2015 (PubMed)
    Show all 2 references for ABIN521952

More Antibodies against PARG Interaction Partners

Human PARG interaction partners

  1. Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX (show H2AFX Antibodies) phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.

  2. Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1 (show NDRG1 Antibodies)) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.

  3. Nuclear Smad (show SMAD1 Antibodies) function is negatively regulated by PARP-1 (show PARP1 Antibodies) that is assisted by PARP-2 (show PARP2 Antibodies) and positively regulated by PARG during the course of TGFB (show TGFB1 Antibodies) signaling.

  4. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.

  5. The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1 (show PARP1 Antibodies)/PARG gene expression balance.

  6. PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.

  7. poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.

  8. Therefore, strategies that target PAR (show JTB Antibodies) metabolism for the improved treatment of cancer may be required to target PARP-1 (show PARP1 Antibodies) and PARG individually in order to optimize cancer cell death.

  9. PARG silencing could inhibit the ability of HUVEC migration and proliferation by downregulating the activity of NF-kappaB (show NFKB1 Antibodies) in LoVo cells that in turn decreases angiogenic factors such as VEGF (show VEGFA Antibodies), b-FGF, ICAM-1 (show ICAM1 Antibodies), MMP-9 (show MMP9 Antibodies), as well as phosphorylation of p38 (show CRK Antibodies) and ERK (show EPHB2 Antibodies).

  10. Silencing of Apoptosis-Inducing factor (show AIFM1 Antibodies) and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

Mouse (Murine) PARG interaction partners

  1. This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.

  2. PARG110 knockout retinal explants were highly resistant to cyclic GMP (show NT5C2 Antibodies) toxicity.

  3. we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.

  4. PARG release of PAR (show AFG3L2 Antibodies) attached to nuclear proteins, followed by ARH3 (show ADPRHL2 Antibodies) cleavage of PAR (show AFG3L2 Antibodies), is essential in regulating PAR (show AFG3L2 Antibodies)-dependent apoptosis-inducing factor (show AIFM1 Antibodies) release from mitochondria and parthanatos.

  5. Data indicate that poly(ADP-ribose) glycohydrolase Parg(-/-) cells were more sensitive to gamma-irradiation than poly(ADP-ribose) polymerase-1 Parp-1 (show PARP1 Antibodies)(-/-) cells.

  6. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor (show RARA Antibodies)-dependent gene expression.

  7. Results demonstrate nuclear AIF (show AIFM1 Antibodies) translocation only in PARG-null TS cells, which demonstrates the presence of AIF (show AIFM1 Antibodies)-mediated cell death.

  8. PARP-1 (show PARP1 Antibodies)/PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins

  9. PARG-deficient cells showed a compromised DNA repair and increased genomic instability.

  10. Hydrolysis of PARP (show PARP1 Antibodies) requires PARG.

PARG Antigen Profile

Protein Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Gene names and symbols associated with anti-PARG (PARG) Antibodies

  • poly (ADP-ribose) glycohydrolase (PARG) antibody
  • poly (ADP-ribose) glycohydrolase (Parg) antibody
  • AI413217 antibody
  • PARG99 antibody

Protein level used designations for anti-PARG (PARG) Antibodies

mitochondrial poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase 60 kDa isoform , cytosolic poly(ADP-ribose) glycohydrolase , mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform

GENE ID SPECIES
8505 Homo sapiens
26430 Mus musculus
83507 Rattus norvegicus
281377 Bos taurus
Selected quality suppliers for anti-PARG (PARG) Antibodies
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