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Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. Additionally we are shipping PARG Antibodies (37) and PARG Proteins (5) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PARG 8505 Q86W56
PARG 26430  
PARG 83507 Q9QYM2
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Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
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96 Tests Log in to see 11 to 13 Days
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More ELISA Kits for PARG Interaction Partners

Human PARG interaction partners

  1. Poly(ADP-ribosyl) glycohydrolase (PARG) is involved in cell proliferation and DNA synthesis, with depletion leading to replication-coupled H2AX (show H2AFX ELISA Kits) phosphorylation. In addition, PARG depletion or inhibition slows down individual replication forks similarly to mild chemotherapeutic treatment.

  2. Studies indicate that poly (ADP-ribose) glycohydrolase (PARG) and terminal ADP-ribose glycohydrolase 1 (TARG1 (show NDRG1 ELISA Kits)) are key enzymes in poly(ADP-ribose) polymerases (PARPs)-mediated ADP-ribosylation.

  3. Nuclear Smad (show SMAD1 ELISA Kits) function is negatively regulated by PARP-1 (show PARP1 ELISA Kits) that is assisted by PARP-2 (show PARP2 ELISA Kits) and positively regulated by PARG during the course of TGFB (show TGFB1 ELISA Kits) signaling.

  4. Radiation-induced G2/M arrest was largely suppressed by PARG siRNA in PC-14 and A427 cells, which exhibited significantly enhanced radiosensitivity in response to PARG knockdown.

  5. The amount of poly(ADP-ribose) in a cell is regulated under the control of PARP1 (show PARP1 ELISA Kits)/PARG gene expression balance.

  6. PARG knockdown enhances sensitivity to MMS in MIAPaCa2 and RKO tumor cell lines.

  7. poly(ADP-ribose) glycohydrolase is crucial for Trypanosoma cruzi infection cycle.

  8. Therefore, strategies that target PAR (show JTB ELISA Kits) metabolism for the improved treatment of cancer may be required to target PARP-1 (show PARP1 ELISA Kits) and PARG individually in order to optimize cancer cell death.

  9. PARG silencing could inhibit the ability of HUVEC migration and proliferation by downregulating the activity of NF-kappaB (show NFKB1 ELISA Kits) in LoVo cells that in turn decreases angiogenic factors such as VEGF (show VEGFA ELISA Kits), b-FGF, ICAM-1 (show ICAM1 ELISA Kits), MMP-9 (show MMP9 ELISA Kits), as well as phosphorylation of p38 (show CRK ELISA Kits) and ERK (show EPHB2 ELISA Kits).

  10. Silencing of Apoptosis-Inducing factor (show AIFM1 ELISA Kits) and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy.

Mouse (Murine) PARG interaction partners

  1. This study contributes to the understanding of PARG catalytic and regulatory mechanisms as well as the rational design of PARG inhibitors.

  2. PARG110 knockout retinal explants were highly resistant to cyclic GMP (show NT5C2 ELISA Kits) toxicity.

  3. we investigated the role of PARG in photoreceptor degeneration using the PARG-110 knock out mouse and report for the first time on PARG expression in wild-type and knock-out retina.

  4. PARG release of PAR (show AFG3L2 ELISA Kits) attached to nuclear proteins, followed by ARH3 (show ADPRHL2 ELISA Kits) cleavage of PAR (show AFG3L2 ELISA Kits), is essential in regulating PAR (show AFG3L2 ELISA Kits)-dependent apoptosis-inducing factor (show AIFM1 ELISA Kits) release from mitochondria and parthanatos.

  5. Data indicate that poly(ADP-ribose) glycohydrolase Parg(-/-) cells were more sensitive to gamma-irradiation than poly(ADP-ribose) polymerase-1 Parp-1 (show PARP1 ELISA Kits)(-/-) cells.

  6. Results define PARG as a coactivator regulating chromatin remodeling during retinoic acid receptor (show RARA ELISA Kits)-dependent gene expression.

  7. Results demonstrate nuclear AIF (show AIFM1 ELISA Kits) translocation only in PARG-null TS cells, which demonstrates the presence of AIF (show AIFM1 ELISA Kits)-mediated cell death.

  8. PARP-1 (show PARP1 ELISA Kits)/PARG control a cell death signal pathway that operates between five different cell compartments and communicates via three types of chemical messengers: a nucleotide, a cation, and proteins

  9. PARG-deficient cells showed a compromised DNA repair and increased genomic instability.

  10. Hydrolysis of PARP (show PARP1 ELISA Kits) requires PARG.

PARG Antigen Profile

Antigen Summary

Poly(ADP-ribose) glycohydrolase (PARG) is the major enzyme responsible for the catabolism of poly(ADP-ribose), a reversible covalent-modifier of chromosomal proteins. The protein is found in many tissues and may be subject to proteolysis generating smaller, active products.

Gene names and symbols associated with PARG (PARG) ELISA Kits

  • poly (ADP-ribose) glycohydrolase (PARG) antibody
  • poly (ADP-ribose) glycohydrolase (Parg) antibody
  • AI413217 antibody
  • PARG99 antibody

Protein level used designations for PARG (PARG) ELISA Kits

mitochondrial poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase , poly(ADP-ribose) glycohydrolase 60 kDa isoform , cytosolic poly(ADP-ribose) glycohydrolase , mitochondrial poly(ADP-ribose) glycohydrolase 63 kDa isoform

8505 Homo sapiens
26430 Mus musculus
83507 Rattus norvegicus
281377 Bos taurus
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