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PDZ Binding Kinase Proteins (PBK)

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Antibodies (136) and PDZ Binding Kinase Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
Rat PBK PBK 290326  
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Top PDZ Binding Kinase Proteins at antibodies-online.com

Showing 9 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Baculovirus infected Insect Cells Human His tag 50 μg Log in to see 16 Days
$272.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Baculovirus infected Insect Cells Human GST tag   50 μg Log in to see 10 to 12 Days
$570.24
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PBK Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
,
Mouse (Murine)

Top referenced PDZ Binding Kinase Proteins

  1. Human PBK Protein expressed in Baculovirus infected Insect Cells - ABIN2003313 : Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN2003313

  2. Human PBK Protein expressed in Escherichia coli (E. coli) - ABIN668031 : Dougherty, Garcia, Nakano, Livingstone, Norris, Polakiewicz, Wexler, Sofroniew, Kornblum, Geschwind: PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 (PubMed)
    Show all 2 references for ABIN668031

More Proteins for PDZ Binding Kinase (PBK) Interaction Partners

Human PDZ Binding Kinase (PBK) interaction partners

  1. Overexpression of Nrf2 (show GABPA Proteins) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Proteins) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Proteins) production and apoptosis.

  2. The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.

  3. TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer

  4. Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP (show ZNF167 Proteins) linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 (show CDK1 Proteins) and linker phosphorylation in mitosis.

  5. PBK/TOPK expression is closely associated with cervical cancer and cervical intraepithelial neoplasia, which may be served as a useful target for tumor diagnosis and immunotherapy.

  6. TOPK, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.

  7. PDZ-binding kinase/T-LAK cell-originated protein kinase correlates with mutant p53 (show TP53 Proteins) and affects cell proliferation and viability as well as prognosis in lung adenocarcinoma

  8. Study findings suggest that the PBK/TOPK mRNA/protein expression is specific to human bladder cancer and might be used as a novel target for development of cancer immunotherapy and diagnostic biomarker.

  9. CHFR (show CHFR Proteins) ubiquitinates and regulates TOPK levels, which is essential for its checkpoint function.

  10. TOPK protein upregulates iNOS (show NOS2 Proteins) gene expression in T cell leukemia Jurkat cells or macrophage leukemic Raw 264.7 cells via NF-kappaB (show NFKB1 Proteins) activation in response to LPS (show IRF6 Proteins), and might act as a critical effector in LPS/TLR4 (show TLR4 Proteins)-mediated signaling cascade.

Mouse (Murine) PDZ Binding Kinase (PBK) interaction partners

  1. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Proteins) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Proteins) signaling pathway.

  2. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  3. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Protein Profile

Protein Summary

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene names and symbols associated with PDZ Binding Kinase Proteins (PBK)

  • PDZ binding kinase (PBK)
  • PDZ binding kinase (pbk)
  • PDZ binding kinase (LOC100341076)
  • PDZ binding kinase (Pbk)
  • 2810434B10Rik protein
  • AW538537 protein
  • CT84 protein
  • D14Ertd732e protein
  • Nori-3 protein
  • PBK protein
  • SPK protein
  • TOPK protein
  • zgc:92050 protein

Protein level used designations for PDZ Binding Kinase Proteins (PBK)

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPECIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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