anti-PDZ Binding Kinase (PBK) Antibodies

PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Proteins (12) and PDZ Binding Kinase Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PBK 55872 Q96KB5
PBK 52033 Q9JJ78
PBK 290326  
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Top anti-PDZ Binding Kinase Antibodies at antibodies-online.com

Showing 10 out of 139 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-PBK Antibody Titration: 0.2-1 ug/mlPositive Control: 721_B cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Mouse Un-conjugated IF, WB Western blot analysis of PBK on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the anti-PBK antibody. 50 μg Log in to see 6 to 8 Days
$154.07
Details
Human Mouse Un-conjugated ICC, FACS, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Flow cytometric analysis of Hela cells using PBK mouse mAb (green) and negative control (red) . 100 μL Log in to see 2 to 3 Days
$430.10
Details
Human Rabbit Un-conjugated IHC (p), WB Anti- PBK Picoband antibody, IHC(P) IHC(P): Mouse Testis Tissue Anti- PBK Picoband antibody, Western blotting All lanes: Anti PBK  at 0.5ug/ml Lane 1: Rat Testis Tissue Lysate at 50ug Lane 2: Mouse Testis Tissue Lysate at 50ug Lane 3: Human Placenta Tissue Lysate at 50ug Lane 4: JURKAT Whole Cell Lysate at 40ug Predicted bind size: 36KD Observed bind size: 36KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB Mouse Pbk Antibody (N-term) (ABIN1881635) western blot analysis in MDA-MB453 cell line lysates (35 µg/lane). This demonstrates the Mouse Pbk antibody detected the Mouse Pbk protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of PBK (arrow) using rabbit polyclonal PBK Antibody (C-term C300) (ABIN391245).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the PBK gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human testis tissue reacted with PBK Antibody (C-term C300) (ABIN391245), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: PBK Antibody [NBP1-84342] - Lane 1: Marker [kDa] 220, 112, 84, 47, 32, 26, 17.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunocytochemistry/Immunofluorescence: PBK Antibody [NBP1-84342] - Staining of mouse medulla shows positivity in a subset of cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$175.80
Details

PBK Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-PDZ Binding Kinase Antibodies

  1. Human Monoclonal PBK Primary Antibody for IF, WB - ABIN968771 : Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for 968771

  2. Human Monoclonal PBK Primary Antibody for ICC, FACS - ABIN969345 : Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007 (PubMed)
    Show all 2 references for 969345

  3. Human Polyclonal PBK Primary Antibody for WB - ABIN1881635 : Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006 (PubMed)
    Show all 2 references for 1881635

  4. Human Polyclonal PBK Primary Antibody for ICC, IF - ABIN4343992 : Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009 (PubMed)

  5. Cow (Bovine) Polyclonal PBK Primary Antibody for WB - ABIN2783527 : Uhl, Liu, Drgon, Johnson, Walther, Rose, David, Niaura, Lerman: Molecular genetics of successful smoking cessation: convergent genome-wide association study results. in Archives of general psychiatry 2008 (PubMed)

More Antibodies against PDZ Binding Kinase Interaction Partners

Human PDZ Binding Kinase (PBK) interaction partners

  1. Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.

  2. PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.

  3. A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.

  4. findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC

  5. TOPK silencing sensitizes EGFR (show EGFR Antibodies)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.

  6. Study shows that BUB1beta (show BUB1B Antibodies) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.

  7. Overexpression of Nrf2 (show GABPA Antibodies) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Antibodies) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Antibodies) production and apoptosis.

  8. The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.

  9. TOPK was speculated to be one of a potential marker and therapeutic target in advanced prostate cancer

  10. Authors identified TOPK/PBK, in vitro and in vivo, as the master ZFP (show ZNF167 Antibodies) linker kinase. Furthermore, they show precise temporal correlation between TOPK activating phosphorylation by Cdk1 (show CDK1 Antibodies) and linker phosphorylation in mitosis.

Mouse (Murine) PDZ Binding Kinase (PBK) interaction partners

  1. this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) signaling pathway

  2. T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Antibodies) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Antibodies) signaling pathway.

  3. The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.

  4. Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.

PDZ Binding Kinase (PBK) Antigen Profile

Protein Summary

This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.

Gene names and symbols associated with PBK

  • PDZ binding kinase (PBK) antibody
  • PDZ binding kinase (pbk) antibody
  • PDZ binding kinase (LOC100341076) antibody
  • PDZ binding kinase (Pbk) antibody
  • 2810434B10Rik antibody
  • AW538537 antibody
  • CT84 antibody
  • D14Ertd732e antibody
  • Nori-3 antibody
  • PBK antibody
  • SPK antibody
  • TOPK antibody
  • zgc:92050 antibody

Protein level used designations for PBK

PDZ binding kinase , T-LAK cell-originated protein kinase , MAPKK-like protein kinase , cancer/testis antigen 84 , lymphokine-activated killer T-cell-originated protein kinase , serine/threonine protein kinase , spermatogenesis-related protein kinase , PDZ-binding kinase , PBK, PDZ-binding kinase , lymphokine-activated killer T-cell-originated protein kinase homolog

GENE ID SPECIES
422003 Gallus gallus
464496 Pan troglodytes
496810 Xenopus (Silurana) tropicalis
713242 Macaca mulatta
100341076 Oryctolagus cuniculus
100587879 Nomascus leucogenys
55872 Homo sapiens
52033 Mus musculus
360218 Danio rerio
496340 Xenopus laevis
477371 Canis lupus familiaris
100141310 Sus scrofa
534781 Bos taurus
290326 Rattus norvegicus
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