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PBKs encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Additionally we are shipping PDZ Binding Kinase Proteins (14) and PDZ Binding Kinase Kits (6) and many more products for this protein.
Showing 10 out of 142 products:
Human Monoclonal PBK Primary Antibody for IF, WB - ABIN968771
Abe, Matsumoto, Kito, Ueda: Cloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cells. in The Journal of biological chemistry 2000
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Human Monoclonal PBK Primary Antibody for IF, WB - ABIN968772
Gaudet, Branton, Lue: Characterization of PDZ-binding kinase, a mitotic kinase. in Proceedings of the National Academy of Sciences of the United States of America 2000
Show all 3 Pubmed References
Human Polyclonal PBK Primary Antibody for WB - ABIN1881635
Zykova, Zhu, Lu, Higgins, Tatsumi, Abe, Bode, Dong: Lymphokine-activated killer T-cell-originated protein kinase phosphorylation of histone H2AX prevents arsenite-induced apoptosis in RPMI7951 melanoma cells. in Clinical cancer research : an official journal of the American Association for Cancer Research 2006
Show all 2 Pubmed References
Human Monoclonal PBK Primary Antibody for ICC, FACS - ABIN969345
Oh, Zhu, Cho, Lee, Kang, Kim, Zykova, Bode, Dong: T-lymphokine-activated killer cell-originated protein kinase functions as a positive regulator of c-Jun-NH2-kinase 1 signaling and H-Ras-induced cell transformation. in Cancer research 2007
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Human Polyclonal PBK Primary Antibody for ICC, IF - ABIN4343992
Mulder, Björling, Jonasson, Wernérus, Hober, Hökfelt, Uhlén: Tissue profiling of the mammalian central nervous system using human antibody-based proteomics. in Molecular & cellular proteomics : MCP 2009
MiR (show MLXIP Antibodies)-770-5p and PBK levels were inversely correlated in xenograft model mice.
TOPK knockdown did not alter radiation response in normal tissues, but significantly enhanced radiosensitivity in cancer cells.These findings have clinical relevance, as elevated TOPK protein expression was associated with poorer clinical outcomes in prostate cancer patients treated with radical radiotherapy. TOPK disruption may cause tumour-specific radiosensitisation in multiple different tumour types.
Determined the crystal structure of PBK, which has two phospho-mimicking mutations T9E and T198E. The structural data indicated that PBK may assemble into an inactive dimer in alkaline conditions. Analytical size-exclusion chromatography and analytical ultracentrifugation confirmed that PBK exists in a conformational transition between dimers and monomers at different pH conditions.
PBK/TOPK plays a crucial role in tumour malignant potential through its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer.
A high PBK expression level was correlated with long overall survival in oral squamous cell carcinoma.
findings suggest that PBK/TOPK plays a crucial role in tumor malignant potential through its overexpression in ESCC
TOPK silencing sensitizes EGFR (show EGFR Antibodies)-TKI-resistant lung cancer cells to gefitinib and increases gefitinib efficacy in preclinical lung adenocarcinoma xenograft models.
Study shows that BUB1beta (show BUB1B Antibodies) and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.
Overexpression of Nrf2 (show GABPA Antibodies) inhibited the PBK/TOPK KD-induced decrease in cdc2 (show CDK1 Antibodies) and cyclin B expression and cell cycle arrest, and blocked ROS (show ROS1 Antibodies) production and apoptosis.
The in vitro data have been consistent with a role for PBK/TOPK in facilitating invasion in prostate cancer. PBK could be a prognostic biomarker for prostate cancer that would discriminate aggressive prostate cancer from indolent disease.
this study shows that remote ischemic postconditioning protects against renal ischemia/reperfusion injury via activation of TOPK/PTEN (show PTEN Antibodies)/Akt (show AKT1 Antibodies) signaling pathway
T-LAK cell-originated protein kinase (TOPK) phosphorylation of MKP1 (show DUSP1 Antibodies) protein prevents solar ultraviolet light-induced inflammation through inhibition of the p38 protein (show RNF19A Antibodies) signaling pathway.
The TOPK protein is expressed mainly in the cytosol of spermatocytes and spermatids, but not in spermatids and spermatogonia in situ.
Melanoma cell lines expressing with high levels of TOPK are more resistant to As(3+)-induced apoptosis. Therefore, inhibition of TOPK activity combined with As(3+) treatment may be helpful in the treatment of melanomas.
This genes encodes a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. This mitotic kinase may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis.
PDZ binding kinase
, T-LAK cell-originated protein kinase
, MAPKK-like protein kinase
, cancer/testis antigen 84
, lymphokine-activated killer T-cell-originated protein kinase
, serine/threonine protein kinase
, spermatogenesis-related protein kinase
, PDZ-binding kinase
, PBK, PDZ-binding kinase
, lymphokine-activated killer T-cell-originated protein kinase homolog