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Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels.
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The DNA copy number variations disrupt PDZD2 and GOLPH3 (show GOLPH3 Antibodies) genes predominantly expressed in placenta, and it may represent a novel risk factor for recurrent miscarriage.
This study does not support the association of PDZD2, GOLPH3 (show GOLPH3 Antibodies), and MTMR12 (show MTMR12 Antibodies) genes with schizophrenia.
the first reported multi-PDZ protein (show INADL Antibodies) that is processed by proteolytic cleavage to generate a secreted peptide containing two PDZ (show INADL Antibodies) domains
The mitogenic effect of secreted PDZD2 was concentration-dependent, and was associated with a slight inhibition of the insulin (show INS Antibodies) promoter activity at high sPDZD2 concentrations.
Results show that a novel pancreatic developmental factor, PDZD2, is sufficient to promote the proliferation of human fetal PPCs (show PPCS Antibodies) while limiting differentiation of ICCs into islet/endocrine cells.
sPDZD2 sensitized mutant p53 (show TP53 Antibodies)-positive DU145 cells and wild-type p53 (show TP53 Antibodies)-positive MCF-7 cells to apoptosis induction through genotoxic stress imposed by sub-lethal concentration of hydrogen peroxide
PDZ-domain containing-2 (PDZD2) drives the maturity of human fetal pancreatic progenitor-derived islet-like cell clusters with functional responsiveness against membrane depolarization.
Results provide the first evidence that Pdzd2 is required for normal regulation of basal insulin (show INS Antibodies) secretion.
These findings reveal that Pdzd2 and p11 (show S100A10 Antibodies) play collaborative roles in regulation of Na(V)1.8 (show SCN10A Antibodies) expression in sensory neurons.
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling. The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.
PDZ domain containing 3
, PDZ domain-containing protein 2
, PDZ domain-containing protein 3
, activated in prostate cancer protein
, plakophilin-related armadillo repeat protein-interacting PDZ protein