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PDZ and LIM Domain 2 (Mystique) (PDLIM2) ELISA Kits

PDLIM2 encodes a member of the ALP subfamily of PDZ-LIM domain proteins. Additionally we are shipping PDLIM2 Antibodies (44) and PDLIM2 Proteins (7) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse PDLIM2 PDLIM2 213019 Q8R1G6
Anti-Rat PDLIM2 PDLIM2 290354 Q6AYD6
Anti-Human PDLIM2 PDLIM2 64236 Q96JY6
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More ELISA Kits for PDLIM2 Interaction Partners

Mouse (Murine) PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. Deficiency in PDLIM2 resulted in the accumulation of STAT3 (show STAT3 ELISA Kits) in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.

  2. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  3. OPN (show SPP1 ELISA Kits) was necessary for PDLIM2 serine phosphorylation and STAT1 (show STAT1 ELISA Kits) ubiquitination in bone marrow macrophages.

  4. PDLIM2 expression was sufficient to suppress in vitro anchorage-independent growth and in vivo tumor formation of colon cancer. PDLIM2 repression involves promoter methylation.

  5. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

  6. SLIM is a novel ubiquitin E3 ligase whose targets include STAT (show STAT1 ELISA Kits) proteins.

  7. PDLIM2 deficiency resulted in larger amounts of nuclear p65 (show NFkBP65 ELISA Kits), defective p65 (show NFkBP65 ELISA Kits) ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli

  8. Stat-interacting LIM protein as the critical Stat (show STAT1 ELISA Kits) ubiquitin E3 ligase involved in osteopontin (show SPP1 ELISA Kits) regulation of Stat1 (show STAT1 ELISA Kits).

  9. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB (show NFKB1 ELISA Kits) transcription reporter activity, and increased LPS (show TLR4 ELISA Kits)-induced TNF-alpha (show TNF ELISA Kits) production.

Human PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.

  2. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth

  3. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA (show RHOA ELISA Kits) signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.

  4. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 (show COPS8 ELISA Kits) signalosome activity.

  5. PDLIM2 was a direct target gene of 1,25(OH)2D3

  6. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  7. PDLIM2 binds to Tax (show CNTN2 ELISA Kits) directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254.

  8. PDLIM2, an essential terminator of NF-kappaB (show NFKB1 ELISA Kits) activation, is repressed in both estrogen receptor (show ESR1 ELISA Kits)-positive and estrogen receptor (show ESR1 ELISA Kits)-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB (show NFKB1 ELISA Kits).

  9. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax (show CNTN2 ELISA Kits) because neither short-term induction nor long-term stable expression of Tax (show CNTN2 ELISA Kits) could downregulate PDLIM2 expression.

  10. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

PDLIM2 Antigen Profile

Antigen Summary

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDLIM2

  • PDZ and LIM domain 2 (Pdlim2) antibody
  • PDZ and LIM domain 2 (mystique) (PDLIM2) antibody
  • 4732462F18Rik antibody
  • MYSTIQUE antibody
  • SLIM antibody

Protein level used designations for PDLIM2

PDZ and LIM domain protein 2 , PDZ-LIM protein mystique , STAT-interacting LIM protein , mystique , alpha-actinins and filamin-interacting protein

GENE ID SPECIES
213019 Mus musculus
290354 Rattus norvegicus
64236 Homo sapiens
512907 Bos taurus
486123 Canis lupus familiaris
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