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PDZ and LIM Domain 2 (Mystique) Proteins (PDLIM2)

PDLIM2 encodes a member of the ALP subfamily of PDZ-LIM domain proteins. Additionally we are shipping PDLIM2 Antibodies (47) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDLIM2 213019 Q8R1G6
Rat PDLIM2 PDLIM2 290354 Q6AYD6
PDLIM2 64236 Q96JY6
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Top PDLIM2 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,946.17
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$2,959.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PDLIM2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for PDZ and LIM Domain 2 (Mystique) (PDLIM2) Interaction Partners

Mouse (Murine) PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. Deficiency in PDLIM2 resulted in the accumulation of STAT3 (show STAT3 Proteins) in the nucleus, enhanced the extent of TH17 cell differentiation, and exacerbated granuloma formation.

  2. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  3. OPN (show SPP1 Proteins) was necessary for PDLIM2 serine phosphorylation and STAT1 (show STAT1 Proteins) ubiquitination in bone marrow macrophages.

  4. PDLIM2 expression was sufficient to suppress in vitro anchorage-independent growth and in vivo tumor formation of colon cancer. PDLIM2 repression involves promoter methylation.

  5. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

  6. SLIM is a novel ubiquitin E3 ligase whose targets include STAT (show STAT1 Proteins) proteins.

  7. PDLIM2 deficiency resulted in larger amounts of nuclear p65 (show NFkBP65 Proteins), defective p65 (show NFkBP65 Proteins) ubiquitination and augmented production of proinflammatory cytokines in response to innate stimuli

  8. Stat-interacting LIM protein as the critical Stat (show STAT1 Proteins) ubiquitin E3 ligase involved in osteopontin (show SPP1 Proteins) regulation of Stat1 (show STAT1 Proteins).

  9. Suppression of PDLIM2 expression resulted in decreased cell adhesion, increased NF-kappaB (show NFKB1 Proteins) transcription reporter activity, and increased LPS (show TLR4 Proteins)-induced TNF-alpha (show TNF Proteins) production.

Human PDZ and LIM Domain 2 (Mystique) (PDLIM2) interaction partners

  1. The suppression of PDLIM2 expression significantly reduced cell proliferation, cell growth and neoplasm invasiveness in prostate cancer cells.

  2. epigenetic repression of PDLIM2 can be reversed by 5-aza-2-deoxycytidine and vitamin D to suppress KSHV-associated cancer cell growth

  3. PDLIM2 expression is essential for feedback regulation of the beta1-integrin-RhoA (show RHOA Proteins) signalling axis and integration of cellular microenvironment signals with gene expression to control the polarity of breast epithelial acini structures.

  4. PDLIM2 integrates cytoskeleton signaling with gene expression in epithelial differentiation by controlling the stability of key transcription factors and COP9 (show COPS8 Proteins) signalosome activity.

  5. PDLIM2 was a direct target gene of 1,25(OH)2D3

  6. Pdlim2 is a novel actin-regulating protein of podocyte foot processes that may have a role in the pathogenesis of glomerular diseases.

  7. PDLIM2 binds to Tax (show CNTN2 Proteins) directly, which was mediated by a putative alpa-helix motif of PDLIM2 at amino acids 236-254.

  8. PDLIM2, an essential terminator of NF-kappaB (show NFKB1 Proteins) activation, is repressed in both estrogen receptor (show ESR1 Proteins)-positive and estrogen receptor (show ESR1 Proteins)-negative breast cancer cells, suggesting one important mechanism for the constitutive activation of NF-kappaB (show NFKB1 Proteins).

  9. Data show that the PDLIM2 repression was independent of the viral regulatory protein Tax (show CNTN2 Proteins) because neither short-term induction nor long-term stable expression of Tax (show CNTN2 Proteins) could downregulate PDLIM2 expression.

  10. Knockdown of Mystique 2 with small interfering RNA abrogated both adhesion and migration in MCF10A and MCF-7 cells

PDLIM2 Protein Profile

Protein Summary

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with PDLIM2

  • PDZ and LIM domain 2 (Pdlim2)
  • PDZ and LIM domain 2 (mystique) (PDLIM2)
  • 4732462F18Rik protein
  • MYSTIQUE protein
  • SLIM protein

Protein level used designations for PDLIM2

PDZ and LIM domain protein 2 , PDZ-LIM protein mystique , STAT-interacting LIM protein , mystique , alpha-actinins and filamin-interacting protein

GENE ID SPECIES
213019 Mus musculus
290354 Rattus norvegicus
64236 Homo sapiens
512907 Bos taurus
486123 Canis lupus familiaris
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