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catalyzes conversion of prostaglandin H2 to prostaglandin D2, a major prostaglandin that mediates sleep, body temperature, hormone release, and odor responses. Additionally we are shipping PGD Synthetase Kits (20) and PGD Synthetase Proteins (1) and many more products for this protein.
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Exposure of macrophages to cyclooxygenase (COX-2 (show COX2 Antibodies)) inhibitors RhoA (show RHOA Antibodies) and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 (show PTGDS Antibodies) receptors or the hepatocyte growth factor (HGF (show HGF Antibodies)) receptor c-Met (PHA (show LBR Antibodies)-665752), reversed EMT (show ITK Antibodies) inhibition by the conditioned medium
Ptgds (show PTGDS Antibodies) is targeted and repressed by the CUL4B (show CUL4B Antibodies)/PRC2 complex.
Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP(+), and NADH.
Prostaglandin D2 synthase is a novel MR target (show PTGDS Antibodies) gene in adipocytes.
When prostaglandin D2 synthase (show PTGDS Antibodies) is upregulated it participates in the regulation of peripheral nervous system myelination.
expression of L-PGDS (show PTGDS Antibodies) in mouse lungs decreased neutrophilic infiltration, ameliorating lung inflammation in mice.
Silencing of PTGDS (show PTGDS Antibodies) also alleviated H-rev107 (show HRASLS Antibodies)-mediated suppression of cell migration and invasion
In this report, we show for the first time that alteration of the P (show PTGDS Antibodies)TGDS-governed PGD2 pathway disturbs testicular migration in mice.
Data indicate a PLA2G3 (show PLA2G3 Antibodies)-lipocalin (show APOD Antibodies)-type PGD2 synthase (L-PGDS)-PGD2 (show PTGDS Antibodies) receptor DP1 (show PTGDR Antibodies) loop that drives mast cell maturation.
The levels of lipocalin (show APOD Antibodies)-type prostaglandin D2 synthase (show PTGDS Antibodies), and its product PGD2 (show PTGDS Antibodies) each varied significantly among background strains of mice after wounding, and the highest Ptgds (show PTGDS Antibodies) and PGD2 (show PTGDS Antibodies) levels were associated with the lowest amount of regeneration.
Serum levels of beta trace protein and beta 2 microglobulin (show B2M Antibodies) can be used to predict residual kidney function in hemodialysis patients.
BTP and B2M (show B2M Antibodies) levels are less affected than serum by amputation, and should be considered for future study of GFR (show RAPGEF5 Antibodies) estimation
Hematopoietic prostaglandin D synthase (show HPGDS Antibodies) defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function
levels of L-PGDS (show PTGDS Antibodies) in cervicovaginal secretions of pregnant women at different stages of parturition correlate with preterm birth.
PTGDS (show PTGDS Antibodies) mRNA expression was down-regulated in rapid-cycling bipolar disorder patients in a euthymic, depressive, and manic/hypomanic state compared with healthy control subjects.
Expression of MR and prostaglandin D2 synthase (show PTGDS Antibodies) is strongly correlated in adipose tissues from obese patients.
These data indicate that scalp is spatially programmed via mast cell prostaglandin D-synthase (show PTGDS Antibodies) distribution in a manner reminiscent of the pattern seen in androgenetic alopecia.
These results suggest that L-PGDS (show PTGDS Antibodies) acted as a scavenger of biliverdin, which is a molecule not found in normal CSF (show CSF2 Antibodies).
Lipocalin (show APOD Antibodies)-type prostaglandin D2 (PGD2) synthase (L-PGDS) interacts intracellularly with the G protein-coupled receptor (show ADRA1A Antibodies) DP1 (show PTGDR Antibodies) in an agonist-independent manner.
Among NSTE-ACS (show PLA2G15 Antibodies) patients, BTP and CysC (show CST3 Antibodies) were superior to conventional renal parameters for predicting MB, and improved clinical stratification for hemorrhagic risk.
The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep.
, glutathione-independent PGD synthase
, glutathione-independent PGD synthetase
, lipocalin-type prostaglandin-D synthase
, prostaglandin D2 synthase (21 kDa, brain)
, prostaglandin-D2 synthase
, prostaglandin-H2 D-isomerase
, Prostaglandin D synthase
, beta-trace protein
, lipocalin-type prostaglandin D synthase
, prostaglandin D synthase