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PHF1 encodes a Polycomb group protein. Additionally we are shipping PHF1 Antibodies (50) and PHF1 Kits (3) and many more products for this protein.
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the F61L/S86F mutant of MTF2 (show MTF2 Proteins) Tudor-PHD1 (show EGLN2 Proteins) was able to bind to H3K36me3 as strong as the PHF1 Tudor bound to this PTM . We concluded that the hydrophobic patch plays an essential role in binding of these Tudors to methylated chromatin
PCL1 binds to and stabilizes p53 (show TP53 Proteins) to induce cellular quiescence
full-length PHF1 in HEK293 cells co-localizes with histone K27me3, but not with K36me3, and this co-localization depends on the trimethyllysine binding pocket indicating that K27me3 is an in vivo target for the PHF1 Tudor domain
present two more ESS with MEAF6 (show MEAF6 Proteins)/PHF1 detected by transcriptome sequencing (case 1) and RT-PCR (case 2), proving that this fusion is recurrent in ESS
ZC3H7B-BCOR (show BCOR Proteins) and MEAF6 (show MEAF6 Proteins)-PHF1 fusions occurred predominantly in S100 protein-negative and malignant OFMT.
Underscore the likely importance of PHF1 rearrangements in the pathogenesis of ossifying fibromyxoid tumors of soft parts.
Morphological features, immunoprofile and fluorescence in situ hybridization rearrangements of JAZF1 (show JAZF1 Proteins) and PHF1 genes were correlated with tumor category and outcome in endometrial sarcomas
The histone H3K36me3 binding by the Tudor domains of PHF1, PHF19 (show PHF19 Proteins) and likely MTF2 (show MTF2 Proteins) provide another recruitment and regulatory mechanism for the PRC2 complex.
All endometrial stromal sarcomas showing sex cords had PHF1 genetic rearrangement, suggesting that such rearrangements may induce sex cord differentiation.
Polycomb group protein PHF1 regulates p53 (show TP53 Proteins)-dependent cell growth arrest and apoptosis
This gene encodes a Polycomb group protein. The protein is a component of a histone H3 lysine-27 (H3K27)-specific methyltransferase complex, and functions in transcriptional repression of homeotic genes. The protein is also recruited to double-strand breaks, and reduced protein levels results in X-ray sensitivity and increased homologous recombination. Multiple transcript variants encoding different isoforms have been found for this gene.
PHD finger protein 1
, polycomblike PCL1
, PHD finger protein 1-like
, polycomb-like protein 1
, tudor domain containing 19C
, t-complex testis-expressed 3
, T-complex testis-expressed 3
, polycomb-like 1