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PHF10 contains a predicted ORF that encodes a protein with two zinc finger domains. Additionally we are shipping PHD Finger Protein 10 Antibodies (15) and PHD Finger Protein 10 Proteins (8) and many more products for this protein.
We studied the expression of S100A4 (show S100A4 ELISA Kits) and the total PHF10 protein in some human cancer cell lines. We have found that, in the cell lines studied, the PHF10 expression is correlated with the S100A4 (show S100A4 ELISA Kits) expression.
Phosphorylation of PHF10 isoforms occurs while they are incorporated as a subunit of the PBAF complex, and therefore phosphorylation of PHF10 isoforms may play an essential role in regulation of PBAF complex's function and mechanism of action.
The study demonstrates the existence of functionally different PBAF complexes in mammalian cell. It also provides an insight into the molecular structure and role of human PHF10/BAF45a and characterizes it as an essential PBAF subunit.
PHF10 repressed caspase-3 (show CASP3 ELISA Kits) expression and impaired the programmed cell death pathway in human gastric cancer at the transcriptional level.
Data show that that PHF10 is required for cell growth.
This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28.
PHD finger protein 10
, BRG1-associated factor 45a
, BRG1-associated factor, 45-KD, A
, PHD zinc finger protein XAP135