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Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Additionally we are shipping PHD Finger Protein 17 Proteins (3) and many more products for this protein.
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Mouse (Murine) Polyclonal PHF17 Primary Antibody for IHC (p), WB - ABIN657355
Foy, Song, Chitalia, Cohen, Saksouk, Cayrou, Vaziri, C�té, Panchenko: Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex. in The Journal of biological chemistry 2008
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Human Polyclonal PHF17 Primary Antibody for WB - ABIN2778354
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
The ciliary protein nephrocystin-4 (show NPHP4 Antibodies) translocates the canonical Wnt (show WNT2 Antibodies) regulator Jade-1 to the nucleus to negatively regulate beta-catenin (show CTNNB1 Antibodies) signaling.
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha (show CSNK1A1 Antibodies) has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
Casein kinase 1 (show CSNK1A1 Antibodies) alpha specifically phosphorylates Jade-1 at an unprimed SLS (show ALDH3A2 Antibodies) phosphorylation site.
Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1 (show MYST2 Antibodies)-JADE1 shuttling during organ regeneration.
lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis.
Reduced Jade-1 expression is associated with clear-cell renal cell carcinomas.
RCC (show XRCC1 Antibodies) with a low expression of Jade-1 is associated with a poor outcome and decreased survival
Jade-1 protein is a novel candidate regulatory factor in Von Hippel Lindau-mediated renal tumor suppression
Jade-1 is a novel candidate transcriptional co-activator associated with HAT (show MGEA5 Antibodies) activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease
Jade-1 may suppress renal cancer cell growth in part by increasing apoptosis.
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor (By similarity).
PHD finger protein 17
, protein Jade-1-like
, protein Jade-1
, PHD protein Jade-1
, gene for apoptosis and differentiation in epithelia
, Jade1 PHD finger protein