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Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Additionally we are shipping PHD Finger Protein 17 Antibodies (41) and many more products for this protein.
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The ciliary protein nephrocystin-4 (show NPHP4 Proteins) translocates the canonical Wnt (show WNT2 Proteins) regulator Jade-1 to the nucleus to negatively regulate beta-catenin (show CTNNB1 Proteins) signaling.
JADE1 expression has a role in colon cancers, renal carcinomas, and in acute kidney injuries and regeneration. (Review)
Interactome analyses revealed that the Jade-1S mutant unable to be phosphorylated by CK1alpha (show CSNK1A1 Proteins) has an increased binding affinity to proteins involved in chromatin remodelling, histone deacetylation, transcriptional repression, and ribosome biogenesis.
Casein kinase 1 (show CSNK1A1 Proteins) alpha specifically phosphorylates Jade-1 at an unprimed SLS (show ALDH3A2 Proteins) phosphorylation site.
Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1 (show MYST2 Proteins)-JADE1 shuttling during organ regeneration.
lncRNA-JADE is a key functional link that connects the DDR to histone H4 acetylation, and that dysregulation of lncRNA-JADE may contribute to breast tumorigenesis.
Reduced Jade-1 expression is associated with clear-cell renal cell carcinomas.
RCC (show XRCC1 Proteins) with a low expression of Jade-1 is associated with a poor outcome and decreased survival
Jade-1 protein is a novel candidate regulatory factor in Von Hippel Lindau-mediated renal tumor suppression
Jade-1 is a novel candidate transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis of renal cancer and von Hippel-Lindau disease
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor (By similarity).
PHD finger protein 17
, protein Jade-1-like
, protein Jade-1
, PHD protein Jade-1
, gene for apoptosis and differentiation in epithelia
, Jade1 PHD finger protein