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The protein encoded by PHF8 is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. Additionally we are shipping PHF8 Antibodies (33) and PHF8 Kits (4) and many more products for this protein.
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PHF8 reduces the H3K9me2 level at the E2F4 (show E2F4 Proteins) transcriptional start site, demonstrating a direct function of PHF8 in endothelial E2F4 (show E2F4 Proteins) gene regulation
PHF2 (show PHF1 Proteins) is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1 (show SUV39H1 Proteins).
PHF8 promotes lung cancer cell growth and survival by regulating miR (show MLXIP Proteins)-21.
knockdown of PHF8 led to a reduction in the number of migratory and invasive cells. Furthermore, downregulation of PHF8 attenuated the tumorigenicity of ESCC cells in vivo.
PHF8 is regulated by APC (show APC Proteins)(cdc20 (show CDC20 Proteins)) and plays an important role in the G2/M transition.
study identified the histone demethylase (show MBD2 Proteins) PHF8 as a coactivator that is specifically recruited by RAR-alpha (show RARA Proteins) fusions to activate expression of their downstream targets upon all-trans retinoic acid treatment in acute promyelocytic leukemia (show PML Proteins)
Results show that PHF8 controls the expression of genes involved in cell adhesion and cytoskeleton organization such as RhoA, Rac1 and GSK3beta.
a role of PHF8 in cell migration and invasion
PHF8 is a histone demethylase and coactivator for RARalpha and that the F279S mutation identified in an XLMR patient results in loss of its demethylase activity.
H3K9me2 level was elevated in the promoter region of the rDNA gene in PHF8 knockdown cells and reduced significantly when the wild type but not the catalytically inactive H247A mutant PHF8 was overexpressed.
PHF8 overexpression reversed cardiac dysfunction, hypertrophy and fibrosis upon pressure overload in PHF8 transgenic mice.
The gene knockdown of PHF8 in mouse embryonic carcinoma P19 cells impairs RA-induced neuronal differentiation.
an important function of PHF8 is in midline formation and in the development of cognitive abilities, and may have a role in X linked mental retardation associated with cleft lip/palate
PHF8 regulates zebrafish neuronal cell survival and jaw development in part by directly regulating the expression of the homeodomain transcription factor MSX1/MSXB, which functions downstream of multiple signalling and developmental pathways
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene.
histone lysine demethylase PHF8
, jumonji C domain-containing histone demethylase 1F
, KIAA1111-like protein
, PHD finger protein 8-like