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Required for ciliogenesis (By similarity).. Additionally we are shipping POC1B Antibodies (34) and many more products for this protein.
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Study indicates that POC1B is required for retinal integrity, and is proposed POC1B mutations as a probable cause for Joubert syndrome with severe polycystic kidney disease.
POC1B is a novel gene for a new disease typical of cone-rod dystrophy except that patients did not report night blindness.
POC1B mutations result in a defect of the photoreceptor sensory cilium and thus affect cone and rod photoreceptors.
Poc1A (show POC1A Proteins) and Poc1B play redundant, but essential, roles in generation of stable centrioles, but Poc1B may have additional independent functions during cell cycle progression.
Poc1B is required for primary ciliogenesis; Poc1 provides a molecular link between the assembly and stability of centrioles for ciliary-based motility in T. thermophila and cilia formation and function in zebrafish and humans
Based on these data, we propose that Pix1 and Pix2 (show POC1A Proteins) are microtubule-associated adaptor proteins that likely contribute to a range of developmental and cell division processes.
data suggest that poc1b is required for normal development and ciliogenesis of retinal photoreceptor sensory cilia and other cilia
Poc1B knockdown causes ciliary defects & morphological phenotype consistent with ciliopathies; Poc1 provides link between assembly & stability of centrioles for ciliary-based motility in Tetrahymena & cilia formation & function in D rerio & humans
Required for ciliogenesis (By similarity).
POC1 centriolar protein homolog B
, WD repeat-containing protein 51B
, WD repeat domain 51B